Incompatibilities between mitochondrial and nuclear genes can perturb respiration,
biosynthesis, signaling and gene expression. Here we investigate whether mild mitonuclear …

Mitochondrial and nuclear genomes have to coevolve to ensure the proper functioning of the
different mitochondrial complexes that are assembled from peptides encoded by both …

Mitochondria are considered major regulators of longevity, although their exact role in aging
is not fully understood. Data from different laboratories show a negative correlation between …

Ever since eukaryotes subsumed the bacterial ancestor of mitochondria, the nuclear and
mitochondrial genomes have had to closely coordinate their activities, as each encode …

Metabolic imbalances accompany the aging process in many organisms, and signaling
mechanisms that allay or prevent these imbalances can extend lifespan. Two recent studies …

Many conserved eukaryotic traits, including apoptosis, two sexes, speciation and ageing,
can be causally linked to a bioenergetic requirement for mitochondrial genes. Mitochondrial …

Among the major challenges in quantitative genetics and personalized medicine is to
understand how gene× gene interactions (G× G: epistasis) and gene× environment …

Aging is often described as an extremely complex process affecting all of the vital
parameters of an individual. In this article, we review how understanding of aging evolved …

Reactive oxygen species (ROS) are generated in mitochondria and are thought to be
important in aging, carcinogenesis, and the development of other pathologies. We now …

Ageing is likely a multifactorial process caused by accumulated damage to a variety of
cellular components. Increasing age in mammals correlates with increased levels of …