Inflammatory bowel diseases (IBD) are defined by the continuous inflammation of the
gastrointestinal tract. During inflammation, the number of pathogens in the intestinal …

Inflammatory bowel diseases are common, complex, immune-mediated conditions with a
sharply rising global prevalence. While major advances since 2000 have provided strong …

Dynamic interactions between the gastrointestinal epithelium and the mucosal immune
system normally contribute to ensuring intestinal homeostasis and optimal …

Ulcerative colitis designates an idiopathic chronic inflammatory bowel disease leading to
bloody diarrhea and inflammatory alterations mostly restricted to the large intestine. Many …

Recent advances have revealed significant insight into inflammatory bowel disease (IBD)
pathobiology. Ulcerative colitis and Crohn's disease, the chronic relapsing clinical …

Genome-wide association studies (GWAS) have revealed risk alleles for ulcerative colitis
(UC). To understand their cell type specificities and pathways of action, we generate an atlas …

Pattern recognition receptors such as nucleotide-binding oligomerization domain (NOD)-
containing protein receptors (NLRs) and the pyrin and hematopoitic interferon-inducible …

Inflammasomes are a large family of multiprotein complexes recognizing pathogen-
associated molecular pattern molecules (PAMPs) and damage-associated molecular …

One of the significant health issues in the world is the prevalence of ulcerative colitis (UC).
UC is a chronic disorder that mainly affects the colon, beginning with the rectum, and can …

The inflammasome is an intracellular molecular complex, which is mainly involved in innate
immunity. Inflammasomes are formed in response to danger signals, associated with …