Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival
BC Özdemir, T Pentcheva-Hoang, JL Carstens… - Cancer cell, 2014 - cell.com
Pancreatic ductal adenocarcinoma (PDAC) is associated with marked fibrosis and stromal
myofibroblasts, but their functional contribution remains unknown. Transgenic mice with the …
myofibroblasts, but their functional contribution remains unknown. Transgenic mice with the …
Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival
BC Özdemir, T Pentcheva-Hoang, JL Carstens… - Cancer cell, 2015 - cell.com
(Cancer Cell 28, 623–637; November 9, 2015) In the originally published version of this
paper, the authors inadvertently omitted an important funding source in the …
paper, the authors inadvertently omitted an important funding source in the …
Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer
Pancreatic stellate cells (PSCs) differentiate into cancer-associated fibroblasts (CAFs) that
produce desmoplastic stroma, thereby modulating disease progression and therapeutic …
produce desmoplastic stroma, thereby modulating disease progression and therapeutic …
IL1-induced JAK/STAT signaling is antagonized by TGFβ to shape CAF heterogeneity in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is poorly responsive to therapies and
histologically contains a paucity of neoplastic cells embedded within a dense desmoplastic …
histologically contains a paucity of neoplastic cells embedded within a dense desmoplastic …
Identification of functional heterogeneity of carcinoma-associated fibroblasts with distinct IL6-mediated therapy resistance in pancreatic cancer
The tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) involves a
significant accumulation of fibroblasts as part of the host response to cancer. Using single …
significant accumulation of fibroblasts as part of the host response to cancer. Using single …
Cancer-associated fibroblast (CAF) heterogeneity and targeting therapy of CAFs in pancreatic cancer
X Geng, H Chen, L Zhao, J Hu, W Yang, G Li… - Frontiers in cell and …, 2021 - frontiersin.org
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease that typically features a
dramatic desmoplastic reaction, especially fibroblasts. The roles of cancer-associated …
dramatic desmoplastic reaction, especially fibroblasts. The roles of cancer-associated …
Interactions between cancer-associated fibroblasts and T cells in the pancreatic tumor microenvironment and the role of chemokines
L Gorchs, H Kaipe - Cancers, 2021 - mdpi.com
Simple Summary Despite advances in therapeutic modalities, the five-year overall survival
for pancreatic cancer is still less than 10%. Pancreatic tumors are characterized by a highly …
for pancreatic cancer is still less than 10%. Pancreatic tumors are characterized by a highly …
Pancreatic cancer associated fibroblasts (CAF): under-explored target for pancreatic cancer treatment
Pancreatic cancer is the 4th leading cause of cancer deaths in the United States. The
pancreatic cancer phenotype is primarily a consequence of oncogenes disturbing the …
pancreatic cancer phenotype is primarily a consequence of oncogenes disturbing the …
Oxidative stress induces monocyte‐to‐myofibroblast transdifferentiation through p38 in pancreatic ductal adenocarcinoma
X Huang, C He, X Hua, A Kan, Y Mao… - Clinical and …, 2020 - Wiley Online Library
Abstract Background Cancer‐associated fibroblasts (CAFs) are among the most prominent
cells during the desmoplastic reaction in pancreatic ductal adenocarcinoma (PDAC) …
cells during the desmoplastic reaction in pancreatic ductal adenocarcinoma (PDAC) …
Tumor cell–derived IL1β promotes desmoplasia and immune suppression in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDA) is an aggressive malignancy typified by a highly
stromal and weakly immunogenic tumor microenvironment that promotes tumor evolution …
stromal and weakly immunogenic tumor microenvironment that promotes tumor evolution …