Kidney toxicity is one of the most frequent adverse events reported during drug
development. The lack of accurate predictive cell culture models and the unreliability of …

The renal proximal tubule epithelium is responsible for active secretion of endogenous and
exogenous waste products from the body and simultaneous reabsorption of vital compounds …

Renal disease is a global problem with unsustainable health-care costs. There currently
exists a lack of accurate human renal disease models that take into account the complex …

Improved model systems to predict drug efficacy, interactions, and drug-induced kidney
injury (DIKI) are crucially needed in drug development. Organ-on-a-chip technology is a …

Background: Kidney dysfunction resulting from various drugs is an important issue during
the drug development process. Traditional in vivo animal experiments are limited with …

Background Kidney disease modeling and assessment of drug-induced kidney injury can be
advanced using three-dimensional (3D) microfluidic models that recapitulate in vivo …

The kidney is frequently involved in adverse effects caused by exposure to foreign
compounds, including drugs. An early prediction of those effects is crucial for allowing novel …

The function and susceptibility of various drugs are tested with renal proximal tubular
epithelial cells; yet, replicating the morphology and kidneys function using the currently …

Traditional approaches to pathophysiology are advancing but still have many limitations that
arise from real biologic systems and their associated physiological phenomena being too …

Proximal tubules in the kidney play a crucial role in reabsorbing and eliminating substrates
from the body into the urine, leading to high local concentrations of xenobiotics. This makes …