The mammalian liver comprises heterogeneous cell types within its tissue microenvironment
that undergo pathophysiological reprogramming in disease states, such as non-alcoholic …

Nonalcoholic steatohepatitis (NASH) is characterized by progressive liver injury,
inflammation, and fibrosis; however, the mechanisms that govern the transition from hepatic …

The incidence of hepatocellular carcinoma (HCC) is rapidly rising largely because of
increased obesity leading to nonalcoholic steatohepatitis (NASH), a known HCC risk factor …

Background & Aims Non-alcoholic fatty liver disease (NAFLD), the hepatic correlate of the
metabolic syndrome, is a major risk factor for hepatobiliary cancer (HBC). Although chronic …

Progression of fatty liver to non-alcoholic steatohepatitis (NASH) is a rapidly growing health
problem. The presence of inflammatory infiltrates in the liver and hepatocyte damage …

In association with the pandemic spreading of obesity and metabolic syndrome, the
prevalence of NAFLD‐related HCC is increasing almost exponentially. In recent years, many …

Hepatocellular carcinoma (HCC), the fastest rising cancer in the United States and
increasing in Europe, often occurs with nonalcoholic steatohepatitis (NASH). Mechanisms …

Obesity increases the risk of hepatocellular carcinoma (HCC) especially in men, but the
molecular mechanism remains obscure. Here, we show that an androgen receptor (AR) …

Endoplasmic reticulum (ER) stress has been implicated in the pathogenesis of viral
hepatitis, insulin resistance, hepatosteatosis, and nonalcoholic steatohepatitis (NASH) …

Studies of animals with obesity-related liver disease have taught us much about the
mechanisms that mediate this pathology. Our work with genetically obese, insulin-resistant …