There are fundamental differences between humans and the animals we typically use to
study the immune system. We have learned much from genetically manipulated and inbred …

With the increase in knowledge resulting from the sequencing of the human genome, the
genetic basis for the underlying differences in individuals, their diseases, and how they …

Highlights•High-quality transcriptomes have been obtained for∼ 270 mouse leukocyte
subsets.•Discoveries include new phenotyping markers, new subsets, and novel …

BACKGROUND The mammalian immune system is a remarkable sensory system for the
detection and neutralization of pathogens. History is replete with the devastating effects of …

Animal models have been tremendously useful to translational research, but there is a need
to maximize their predictive value to human disease. This Comment proposes novel …

Advances in human genomics, when validated functionally, can lead to new insights into
how the immune system works. Notably, previously unknown mechanisms revealed by …

The two pillars of modern immunology have been man and mouse; in both settings,
investigators seek to reduce complexity and control environmental conditions. However, the …

ImmGen (Immunological Genome Project) is a collaborative group of immunology and
computational biology laboratories that aims to determine, on a broad and highly granular …

Understanding how the immune system is regulated and responds to pathogens will require
whole-system approaches, because the study of single immunological parameters has, so …

Within the field of medical research, animal models are considered valuable research tools
that provide insight into the complex world of human diseases. Inbred animals eliminate …