Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats

M Longmire, PL Choyke, H Kobayashi - 2008 - Future Medicine
Nanoparticles possess enormous potential as diagnostic imaging agents and hold promise
for the development of multimodality agents with both imaging and therapeutic capabilities …

Factors relating to the biodistribution & clearance of nanoparticles & their effects on in vivo application

Y Wei, L Quan, C Zhou, Q Zhan - Nanomedicine, 2018 - Future Medicine
Nanoparticles have promising biomedical applications for drug delivery, tumor imaging and
tumor treatment. Pharmacokinetics are important for the in vivo application of nanoparticles …

Clearance pathways and tumor targeting of imaging nanoparticles

M Yu, J Zheng - ACS nano, 2015 - ACS Publications
A basic understanding of how imaging nanoparticles are removed from the normal
organs/tissues but retained in the tumors is important for their future clinical applications in …

Biodistribution, clearance, and long‐term fate of clinically relevant nanomaterials

J Bourquin, A Milosevic, D Hauser, R Lehner… - Advanced …, 2018 - Wiley Online Library
Realization of the immense potential of nanomaterials for biomedical applications will
require a thorough understanding of how they interact with cells, tissues, and organs. There …

Transport and interactions of nanoparticles in the kidneys

B Du, M Yu, J Zheng - Nature Reviews Materials, 2018 - nature.com
Kidneys are a major organ for blood filtration and waste elimination and thus play a key role
in the transport and clearance of nanoparticles in vivo. The interactions of nanoparticles with …

[PDF][PDF] Imaging nano-bio interactions in the kidney: toward a better understanding of nanoparticle clearance

J Wang, G Liu - Angew. Chem., Int. Ed, 2018 - academia.edu
Inorganic nanoparticle (NP) based imaging contrast agents with tuneable shape, size, and
surface chemistry have immense potential in both basic research and clinical settings …

[HTML][HTML] Renal clearance of nanoparticles

HS Choi, W Liu, P Misra, E Tanaka, JP Zimmer… - Nature …, 2007 - ncbi.nlm.nih.gov
The field of nanotechnology holds great promise for the diagnosis and treatment of human
disease. However, the size and charge of most nanoparticles preclude their efficient …

Biologically optimized nanosized molecules and particles: more than just size

MR Longmire, M Ogawa, PL Choyke… - Bioconjugate …, 2011 - ACS Publications
The expanded biological and medical applications of nanomaterials place a premium on
better understanding of the chemical and physical determinants of in vivo particles …

In vivo biodistribution of nanoparticles

JPM Almeida, AL Chen, A Foster, R Drezek - Nanomedicine, 2011 - Future Medicine
Nanoparticles have potential applications in diagnostics, imaging, gene and drug delivery
and other types of therapy. Iron oxide nanoparticles, gold nanoparticles and quantum dots …

[HTML][HTML] Advantages and limitations of current techniques for analyzing the biodistribution of nanoparticles

L Arms, DW Smith, J Flynn, W Palmer… - Frontiers in …, 2018 - frontiersin.org
Nanomedicines are typically submicrometer-sized carrier materials (nanoparticles)
encapsulating therapeutic and/or imaging compounds that are used for the prevention …