In Singapore, Down syndrome screening is routinely offered to all pregnant women
regardless of age.(1) The most common test offered is the combined first trimester screen …

INTRODUCTION (DIANA W. BIANCHI) Over the past 2 years, noninvasive prenatal testing
(NIPT) or, more precisely, noninvasive DNA testing (NIDT), using massively parallel …

In the last decades, prenatal screening for aneuploidy has become increasingly effective.
While first trimester combined screening is considered to be the current gold standard, the …

Background Non-invasive prenatal test (NIPT) is an intermediate step between serum
screening and invasive diagnostic testing. It involves analysis of the cell-free fetal DNA …

Non-invasive prenatal testing (NIPT) is a new screen for fetal chromosomal abnormalities. It
is a screening test based on technology that involves the analysis of feto-placental DNA that …

OBJECTIVE: Recent studies have reported the efficacy of first-trimester combined screening
for Down syndrome based on maternal age, serum markers (human chorionic gonadotropin …

Non-invasive prenatal testing (NIPT) based on cell free fetal DNA fragments in maternal
serum samples (cffDNA) is a well-established method for Downs-screening in early …

Down syndrome (DS) is the most common human disease caused by a structural
chromosome defect. The original screening test for DS was maternal age or a history of a …

Noninvasive prenatal testing (NIPT) refers to recently developed genetic tests of the
maternal serum that allow higher detection rates of trisomy 21 and other chromosomal …

This method of screening for Down syndrome, described by Wright et al.(Wright et al., 2006)
is unsatisfactory. It will cause unnecessary patient anxiety because many women will have …