A key component of cardiac ischemia–reperfusion injury (IRI) is the increased generation of
reactive oxygen species, leading to enhanced inflammation and tissue dysfunction in …

Cardiovascular disease is the leading cause of death in individuals over 60 years old. Aging
is associated with an increased prevalence of coronary artery disease and a poorer …

Ischemic heart disease (IHD) is defined as a syndrome of ischemic cardiomyopathy.
Myogenesis and angiogenesis in the ischemic myocardium are important for cardiomyocyte …

Cardiovascular diseases (CVD) are predominantly an aging disease. Important sex-specific
differences exist and the mechanism (s) by which this sex-by-age interaction influences CVD …

Aging leads to increased cellular senescence and is associated with decreased potency of
tissue‐specific stem/progenitor cells. Here, we have done an extensive analysis of cardiac …

Cellular senescence within the cardiovascular system has, until recently, been understudied
and unappreciated as a factor in the development of age‐related cardiovascular diseases …

Senescent cell accumulation has been observed in age-associated diseases including
cardiovascular diseases. Senescent cells lack proliferative capacity and secrete senescence …

Aging is a prominent risk factor for cardiovascular diseases, which is the leading cause of
death around the world. Recently, cellular senescence has received potential attention as a …

Replicative capacity of somatic cells is limited. It indicates that aging also develops at the
cellular level, and this is described as “cellular senescence”. Senescent cells become …

Myocardial ischemia-reperfusion (IR) generates stress-induced senescent cells (SISCs) that
play an important role in the pathophysiology of adverse cardiac remodeling and heart …