[HTML][HTML] Integrated phosphoproteome and transcriptome analysis reveals chlamydia-induced epithelial-to-mesenchymal transition in host cells

PK Zadora, C Chumduri, K Imami, H Berger, Y Mi… - Cell Reports, 2019 - cell.com
Chlamydia trachomatis (Ctr) causes a range of infectious diseases and is epidemiologically
associated with cervical and ovarian cancers. To obtain a panoramic view of Ctr-induced …

[HTML][HTML] Role of Epithelial-Mesenchyme Transition in Chlamydia Pathogenesis

JU Igietseme, Y Omosun, O Stuchlik, MS Reed… - PloS one, 2015 - journals.plos.org
Chlamydia trachomatis genital infection in women causes serious adverse reproductive
complications, and is a strong co-factor for human papilloma virus (HPV)-associated cervical …

[HTML][HTML] The role of infected epithelial cells in Chlamydia-associated fibrosis

LT Caven, RA Carabeo - Frontiers in Cellular and Infection …, 2023 - frontiersin.org
Ocular, genital, and anogenital infection by the obligate intracellular pathogen Chlamydia
trachomatis have been consistently associated with scar-forming sequelae. In cases of …

A Loss-of-Function Screen Reveals Ras- and Raf-Independent MEK-ERK Signaling During Chlamydia trachomatis Infection

RK Gurumurthy, AP Mäurer, N Machuy, S Hess… - Science …, 2010 - science.org
Chlamydiae are obligate intracellular bacterial pathogens that have a major effect on human
health. Because of their intimate association with their host, chlamydiae depend on various …

Epidermal Growth Factor Receptor and Transforming Growth Factor β Signaling Pathways Cooperate To Mediate Chlamydia Pathogenesis

JU Igietseme, J Partin, Z George, Y Omosun… - Infection and …, 2020 - Am Soc Microbiol
Human genital Chlamydia infection is a major public health concern due to the serious
reproductive system complications. Chlamydia binds several receptor tyrosine kinases …

[HTML][HTML] Early Transcriptional Landscapes of Chlamydia trachomatis-Infected Epithelial Cells at Single Cell Resolution

RJ Hayward, JW Marsh, MS Humphrys… - Frontiers in cellular …, 2019 - frontiersin.org
Chlamydia are Gram-negative obligate intracellular bacterial pathogens responsible for a
variety of disease in humans and animals worldwide. Chlamydia trachomatis causes …

[HTML][HTML] Chlamydia infection promotes host DNA damage and proliferation but impairs the DNA damage response

C Chumduri, RK Gurumurthy, PK Zadora, Y Mi… - Cell host & …, 2013 - cell.com
The obligate intracellular bacterial pathogen Chlamydia trachomatis (Ctr) has been
associated with cervical and ovarian cancer development. However, establishment of …

Molecular pathogenesis of chlamydia disease complications: epithelial-mesenchymal transition and fibrosis

JU Igietseme, Y Omosun, T Nagy, O Stuchlik… - Infection and …, 2018 - Am Soc Microbiol
The reproductive system complications of genital chlamydial infection include fallopian tube
fibrosis and tubal factor infertility. However, the molecular pathogenesis of these …

[HTML][HTML] The impact of protein phosphorylation on chlamydial physiology

JE Claywell, LM Matschke, DJ Fisher - Frontiers in cellular and …, 2016 - frontiersin.org
Chlamydia are Gram negative bacterial pathogens responsible for disease in humans and
economically important domesticated animals. As obligate intracellular bacteria, they must …

[HTML][HTML] Chlamydia trachomatis-induced alterations in the host cell proteome are required for intracellular growth

AJ Olive, MG Haff, MJ Emanuele, LM Sack, JR Barker… - Cell host & …, 2014 - cell.com
Intracellular pathogens directly alter host cells in order to replicate and survive. While
infection-induced changes in host transcription can be readily assessed, posttranscriptional …