Insights into the role of DNA methylation in immune cell development and autoimmune disease
J Li, L Li, Y Wang, G Huang, X Li, Z Xie… - Frontiers in Cell and …, 2021 - frontiersin.org
To date, nearly 100 autoimmune diseases have been an area of focus, and these diseases
bring health challenges to approximately 5% of the population worldwide. As a type of …
bring health challenges to approximately 5% of the population worldwide. As a type of …
Understanding the relevance of DNA methylation changes in immune differentiation and disease
Immune cells are one of the most complex and diverse systems in the human organism.
Such diversity implies an intricate network of different cell types and interactions that are …
Such diversity implies an intricate network of different cell types and interactions that are …
DNA methylation signatures of autoimmune diseases in human B lymphocytes
M Zouali - Clinical Immunology, 2021 - Elsevier
B lymphocytes play key roles in adaptive and innate immunity. In autoimmune diseases,
their participation in disease instigation and/or progression has been demonstrated in both …
their participation in disease instigation and/or progression has been demonstrated in both …
Contribution of dysregulated DNA methylation to autoimmunity
SC Funes, A Fernández-Fierro… - International Journal of …, 2021 - mdpi.com
Epigenetic mechanisms, such as DNA methylation, histone modifications, and non-coding
RNAs are known regulators of gene expression and genomic stability in cell growth …
RNAs are known regulators of gene expression and genomic stability in cell growth …
DNA methylation as a transcriptional regulator of the immune system
DNA methylation is a dynamic epigenetic modification with a prominent role in determining
mammalian cell development, lineage identity, and transcriptional regulation. Primarily …
mammalian cell development, lineage identity, and transcriptional regulation. Primarily …
The role of DNA methylation in personalized medicine for immune-related diseases
Epigenetics functions as a bridge between host genetic & environmental factors, aiding in
human health and diseases. Many immune-related diseases, including infectious and …
human health and diseases. Many immune-related diseases, including infectious and …
DNA methylation perspectives in the pathogenesis of autoimmune diseases
DNA methylation is now widely recognized as being critical to maintain the function of
immune cells. Recent studies suggest that aberrant DNA methylation levels not only can …
immune cells. Recent studies suggest that aberrant DNA methylation levels not only can …
DNA methylation: a promising landscape for immune system-related diseases
B Suarez-Alvarez, RM Rodriguez, MF Fraga… - Trends in Genetics, 2012 - cell.com
During hematopoiesis, a unique hematopoietic stem cell (HSC) from the bone marrow gives
rise to a subset of mature blood cells that directs all the immune responses. Recent studies …
rise to a subset of mature blood cells that directs all the immune responses. Recent studies …
[HTML][HTML] DNA methylation signatures reveal that distinct combinations of transcription factors specify human immune cell epigenetic identity
Epigenetic reprogramming underlies specification of immune cell lineages, but patterns that
uniquely define immune cell types and the mechanisms by which they are established …
uniquely define immune cell types and the mechanisms by which they are established …
DNA methylation changes on immune cells in systemic lupus erythematosus
C Hurtado, LY Acevedo Saenz… - …, 2020 - Taylor & Francis
DNA methylation as a process that regulates gene expression is crucial in immune cells
biology. Global and gene specific methylation changes have been described in …
biology. Global and gene specific methylation changes have been described in …
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