Calcium homeostasis is a tightly regulated process involving the co-ordinated efforts of the
skeleton, kidney, parathyroid glands and intestine. Neoplasms can alter this homeostasis …

The metastasis of cancer cells to bone alters bone architecture and mineral homeostasis. As
described by the 'seed and soil'hypothesis, bone represents a fertile ground for cancer cells …

Recent discoveries on mechanisms of malignancy-associated hypercalcemia highlight the
critical role of the osteoclast. Bisphosphonates and other novel therapies being evaluated in …

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Bone metastases are common in many advanced cancers and are a clinically relevant
source of skeletal morbidity. The bone mineral matrix contains numerous growth factors that …

In patients with advanced disease, several cancer types frequently metastasize to the
skeleton, where they cause bone destruction. Osteolytic metastases are incurable and …

Certain solid tumors metastasize to bone and cause osteolysis and abnormal new bone
formation. The respective phenotypes of dysregulated bone destruction and bone formation …

Skeletal lesions are a frequent complication of breast and prostate cancer and a hallmark of
multiple myeloma. Endocrine and paracrine factors modulate various aspects of bone …

The variability of different primary tumors in the susceptibility to metastatic bone disease is
poorly understood. Factors that determine the viability of metastatic cells are also poorly …

Osteolytic and osteoblastic metastases are often the cause of considerable morbidity in
patients with advanced prostate and breast carcinoma. Breast carcinoma metastasis to bone …