Obesity and type 2 diabetes (T2D) have been found to be associated with abnormalities in
several organs, including the intestine. These conditions can lead to changes in gut …

Oral tolerance is the active absence of response to food allergens, which involves complex
mechanisms in the gut-associated lymphoid tissue. Food allergy results from the disruption …

Oral tolerance can develop after frequent exposure to food allergens. Upon ingestion, food
is digested into small protein fragments in the gastrointestinal tract. Small food particles are …

Introduction: The increase in high-fat diet (HFD)-induced obesity and food allergy leads to
an assumption that the 2 are related. This study aims to (1) systematic verification of HFD …

Background Processed foods are part of daily life. Almost all processed foods contain food
additives such as sweeteners, preservatives and colourants. From childhood, it is difficult to …

Objective: It is known that immune functions are altered in various ways by obesity.
However, changes in the intestinal immune system resulting from obesity remain poorly …

Increased intestinal permeability is thought to underlie the pathogenesis of food allergy. We
explore the mechanism responsible for changes in the morphology and function of the …

Glucose, the critical energy source in the human body, is considered a potential risk factor in
various autoimmune diseases when consumed in high amounts. However, the roles of …

In our mouse model, gastric acid-suppression is associated with antigen-specific IgE and
anaphylaxis development. We repeatedly observed non-responder animals protected from …

Background Diet-induced obesity and food allergies increase in tandem, but a potential
cause-and-effect relationship between these diseases of affluence remains to be tested …