Tyrosinases are widely distributed in nature. They are copper‐containing oxidases
belonging to the type 3 copper protein family, together with catechol oxidases and …

Tyrosinases are metalloenzymes belonging to the type‐3 copper protein family which
contain two copper ions in the active site. They are found in various prokaryotes as well as in …

The structure of tyrosinase (Tyr) is reviewed from a double point of view. On the one hand,
by comparison of all Tyr found throughout nature, from prokaryotic organisms to mammals …

Mutations of the critical and rate-limiting melanogenic enzyme tyrosinase (Tyr) result in
hypopigmentation of the hair, skin and eyes. Two other related enzymes, Tyrp1 and Dct …

Tyrosinase is responsible for the two initial enzymatic steps in the conversion of tyrosine to
melanin. Many tyrosinase mutations are the leading cause of albinism in humans, and it is a …

Tyrosinase (Tyr) and tyrosinase-related proteins (Tyrps) 1 and 2 are the enzymes
responsible for mammalian melanogenesis. They display high similarity but different …

The production of pigment in mammalian melanocytes requires the contribution of at least
three melanogenic enzymes, tyrosinase and two other accessory enzymes called the …

Tyrosinase, a dinuclear copper monooxygenase/oxidase, plays a crucial role in the melanin
pigment biosynthesis. The structure and functions of tyrosinase have so far been studied …

Melanin is the main pigment responsible for the color of human skin, hair and eye. Its
biosynthesis requires three melanogenic enzymes, tyrosinase (TYR), and the tyrosinase …

Tyrosinase is a member of the type 3 copper enzyme family that is involved in the production
of melanin in a wide range of organisms. The crystal structures of a tyrosinase from Bacillus …