Microglia-mediated calcium-permeable AMPAR accumulation in the nucleus accumbens drives hyperlocomotion during cocaine withdrawal
I Reverte, C Marchetti, S Pezza, SF Zenoni… - Brain, Behavior, and …, 2024 - Elsevier
During withdrawal from cocaine, calcium permeable-AMPA receptors (CP-AMPAR)
progressively accumulate in nucleus accumbens (NAc) synapses, a phenomenon linked to …
progressively accumulate in nucleus accumbens (NAc) synapses, a phenomenon linked to …
Calcium-permeable AMPA receptors in the VTA and nucleus accumbens after cocaine exposure: when, how, and why?
In animal models of drug addiction, cocaine exposure has been shown to increase levels of
calcium-permeable AMPA receptors (CP-AMPARs) in two brain regions that are critical for …
calcium-permeable AMPA receptors (CP-AMPARs) in two brain regions that are critical for …
Renewed cocaine exposure produces transient alterations in nucleus accumbens AMPA receptor-mediated behavior
RK Bachtell, DW Self - Journal of Neuroscience, 2008 - Soc Neuroscience
Withdrawal from repeated cocaine is associated with increased synaptic and extrasynaptic
AMPA receptor (AMPAR) expression in nucleus accumbens (NAc) neurons and enhanced …
AMPA receptor (AMPAR) expression in nucleus accumbens (NAc) neurons and enhanced …
Cocaine-induced sensitization and glutamate plasticity in the nucleus accumbens core: effects of sex
AM Catalfio, TL Fetterly, AM Nieto, TE Robinson… - Biology of sex …, 2023 - Springer
Background The development and persistence of addiction is mediated in part by drug-
induced alterations in nucleus accumbens (NAc) function. AMPA-type glutamate receptors …
induced alterations in nucleus accumbens (NAc) function. AMPA-type glutamate receptors …
Synaptic depotentiation and mGluR5 activity in the nucleus accumbens drive cocaine-primed reinstatement of place preference
MA Benneyworth, MC Hearing, AJ Asp… - Journal of …, 2019 - Soc Neuroscience
Understanding the neurobiological processes that incite drug craving and drive relapse has
the potential to help target efforts to treat addiction. The NAc serves as a critical substrate for …
the potential to help target efforts to treat addiction. The NAc serves as a critical substrate for …
Endogenous dopamine and endocannabinoid signaling mediate cocaine-induced reversal of AMPAR synaptic potentiation in the nucleus accumbens shell
AE Ingebretson, MC Hearing, ED Huffington… - …, 2018 - Elsevier
Repeated exposure to drugs of abuse alters the structure and function of neural circuits
mediating reward, generating maladaptive plasticity in circuits critical for motivated behavior …
mediating reward, generating maladaptive plasticity in circuits critical for motivated behavior …
Cell surface AMPA receptors in the rat nucleus accumbens increase during cocaine withdrawal but internalize after cocaine challenge in association with altered …
AC Boudreau, JM Reimers, M Milovanovic… - Journal of …, 2007 - Soc Neuroscience
Although some studies report increased responsiveness of nucleus accumbens (NAc)
AMPA receptors (AMPARs) after withdrawal from repeated cocaine treatment, others report …
AMPA receptors (AMPARs) after withdrawal from repeated cocaine treatment, others report …
Minocycline prevents chronic restraint stress-induced vulnerability to developing cocaine self-administration and associated glutamatergic mechanisms: a potential …
MP Avalos, AS Guzman, D Rigoni, EA Gorostiza… - Brain, behavior, and …, 2022 - Elsevier
Stressful experience-induced cocaine-related behaviors are associated with a significant
impairment of glutamatergic mechanisms in the Nucleus Accumbens core (NAcore). The …
impairment of glutamatergic mechanisms in the Nucleus Accumbens core (NAcore). The …
Group I mGluR activation reverses cocaine-induced accumulation of calcium-permeable AMPA receptors in nucleus accumbens synapses via a protein kinase C …
JE McCutcheon, JA Loweth, KA Ford… - Journal of …, 2011 - Soc Neuroscience
Following prolonged withdrawal from extended access cocaine self-administration in adult
rats, high conductance Ca2+-permeable AMPA receptors (CP-AMPARs) accumulate in …
rats, high conductance Ca2+-permeable AMPA receptors (CP-AMPARs) accumulate in …
Cell-type specific insertion of GluA2-lacking AMPARs with cocaine exposure leading to sensitization, cue-induced seeking, and incubation of craving
Addiction is a behavioral disease, of which core components can be modeled in rodents.
Much evidence implicates drug-evoked synaptic plasticity in cocaine-evoked locomotor …
Much evidence implicates drug-evoked synaptic plasticity in cocaine-evoked locomotor …