Acute lung injury caused by sepsis: how does it happen?

B Sun, M Lei, J Zhang, H Kang, H Liu, F Zhou - Frontiers in Medicine, 2023 - frontiersin.org
Sepsis is a systemic inflammatory disease caused by severe infections that involves multiple
systemic organs, among which the lung is the most susceptible, leaving patients highly …

Classic Signaling Pathways in Alveolar Injury and Repair Involved in Sepsis‐Induced ALI/ARDS: New Research Progress and Prospect

W Li, D Li, Y Chen, H Abudou, H Wang, J Cai… - Disease …, 2022 - Wiley Online Library
Sepsis is a common critical clinical disease with high mortality that can cause approximately
10 million deaths worldwide each year. Acute lung injury (ALI) or acute respiratory distress …

Advanced development and mechanism of sepsis-related acute respiratory distress syndrome

H Gong, Y Chen, M Chen, J Li, H Zhang, S Yan… - Frontiers in …, 2022 - frontiersin.org
The introduction of the Sepsis 3.0 guidelines in 2016 improved our understanding of sepsis
diagnosis and therapy. Personalized treatment strategies and nursing methods for sepsis …

The pharmacology of acute lung injury in sepsis

BM Varisco - Advances in Pharmacological and …, 2011 - Wiley Online Library
Acute lung injury (ALI) secondary to sepsis is one of the leading causes of death in sepsis.
As such, many pharmacologic and nonpharmacologic strategies have been employed to …

[HTML][HTML] Integrating molecular pathogenesis and clinical translation in sepsis-induced acute respiratory distress syndrome

JA Englert, C Bobba, RM Baron - JCI insight, 2019 - ncbi.nlm.nih.gov
Sepsis-induced acute respiratory distress syndrome (ARDS) has high morbidity and
mortality and arises after lung infection or infection at extrapulmonary sites. An aberrant host …

Sepsis and acute respiratory distress syndrome: recent update

WY Kim, SB Hong - Tuberculosis and respiratory diseases, 2016 - synapse.koreamed.org
Severe sepsis or septic shock is characterized by an excessive inflammatory response to
infectious pathogens. Acute respiratory distress syndrome (ARDS) is a devastating …

Models and mechanisms of acute lung injury caused by direct insults

LK Reiss, U Uhlig, S Uhlig - European journal of cell biology, 2012 - Elsevier
Acute lung injury (ALI) and its more severe form acute respiratory distress syndrome (ARDS)
are life-threatening diseases that are characterized by acute onset, pulmonary inflammation …

A diagnostic model for sepsis-induced acute lung injury using a consensus machine learning approach and its therapeutic implications

Y Zheng, J Wang, Z Ling, J Zhang, Y Zeng… - Journal of Translational …, 2023 - Springer
Background A significant proportion of septic patients with acute lung injury (ALI) are
recognized late due to the absence of an efficient diagnostic test, leading to the postponed …

A two-hit model of sepsis plus hyperoxia causes lung permeability and inflammation

JA Bastarache, K Smith, JJ Jesse… - … of Physiology-Lung …, 2022 - journals.physiology.org
Mouse models of acute lung injury (ALI) have been instrumental for studies of the biological
underpinnings of lung inflammation and permeability, but murine models of sepsis generate …

Lung injury induced by sepsis: lessons learned from large animal models and future directions for treatment

B Sadowitz, S Roy, LA Gatto, N Habashi… - Expert review of anti …, 2011 - Taylor & Francis
Acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) remain common
complications of sepsis. Unfortunately, development of effective pharmacologic and …