Differentiation of proinflammatory CD4+ conventional T cells (T conv) is critical for productive
antitumor responses yet their elicitation remains poorly understood. We comprehensively …

Tumor-infiltrating dendritic cells (DCs) assume varied functional states that impact anti-tumor
immunity. To delineate the DC states associated with productive anti-tumor T cell immunity …

Background The conventional type 1 dendritic cell subset (cDC1) is indispensable for tumor
immune responses and the efficacy of immune checkpoint inhibitor (ICI) therapies in animal …

Cytotoxic CD8+ T cells are potent killers of diseased cells, but their functional capacity is
often compromised in cancer. The quality of antitumor T cell immunity is determined during T …

In tumors, a subset of CD8+ T cells expressing the transcription factor TCF-1 drives the
response to immune checkpoint blockade. We examined the mechanisms that maintain …

Dendritic cells (DCs) are endowed with a unique potency to prime T cells, as well as to
orchestrate their expansion, functional polarization and effector activity in non-lymphoid …

Tumour dendritic cells (DCs) internalise antigen and upregulate CCR7, which directs their
migration to tumour-draining lymph nodes (dLN). CCR7 expression is coupled to an …

CD1d-restricted T cells contribute to tumor protection, but their precise roles remain unclear.
Here we show that tumor cells engineered to secrete granulocyte–macrophage colony …

In cancer patients, dendritic cells (DCs) in tumor-draining lymph nodes can present antigens
to naive T cells in ways that break immunological tolerance. The clonally expanded progeny …

Dendritic cells (DCs) are professional antigen presenting cells with the ability to either
initiate or prevent the induction of antigen-specific T cell responses. The conventional DC …