[HTML][HTML] STIM1 deficiency in intestinal epithelium attenuates colonic inflammation and tumorigenesis by reducing ER stress of goblet cells
X Liang, J Xie, H Liu, R Zhao, W Zhang, H Wang… - Cellular and molecular …, 2022 - Elsevier
Background & Aims As an indispensable component of store-operated Ca 2+ entry, stromal
interaction molecule 1 (STIM1) is known to promote colorectal cancer and T-cell–mediated …
interaction molecule 1 (STIM1) is known to promote colorectal cancer and T-cell–mediated …
STIM1 overexpression promotes colorectal cancer progression, cell motility and COX-2 expression
Tumor metastasis is the major cause of death among cancer patients, with> 90% of cancer-
related death attributable to the spreading of metastatic cells to secondary organs. Store …
related death attributable to the spreading of metastatic cells to secondary organs. Store …
[HTML][HTML] Correlation of clinical features and genetic profiles of stromal interaction molecule 1 (STIM1) in colorectal cancers
HSC Wong, WC Chang - Oncotarget, 2015 - ncbi.nlm.nih.gov
STIM1 overexpression has been observed in a portion of colorectal cancer (CRC) patients
and associated with cancer cell invasion and migration. To characterize the distinctive …
and associated with cancer cell invasion and migration. To characterize the distinctive …
[HTML][HTML] Stromal interaction molecule 1 plays an important role in gastric cancer progression
JM Xu, Y Zhou, L Gao, SX Zhou… - Oncology …, 2016 - spandidos-publications.com
Studies have shown that stromal interaction molecule 1 (STIM1) is expressed in a variety of
cancers and is related to tumor growth. The present study aimed to investigate the …
cancers and is related to tumor growth. The present study aimed to investigate the …
[HTML][HTML] STIM1, a direct target of microRNA-185, promotes tumor metastasis and is associated with poor prognosis in colorectal cancer
Z Zhang, X Liu, B Feng, N Liu, Q Wu, Y Han, Y Nie… - Oncogene, 2015 - nature.com
Abstract STIM1 (stromal interaction molecule 1), an endoplasmic reticulum Ca 2+ sensor
that triggers the store-operated Ca 2+ entry activation, has recently been implicated in …
that triggers the store-operated Ca 2+ entry activation, has recently been implicated in …
[HTML][HTML] Functional consequences of enhanced expression of STIM1 and Orai1 in Huh-7 hepatocellular carcinoma tumor-initiating cells
Background The endoplasmic reticulum (ER) Ca 2+ sensor, stromal interaction molecule1
(STIM1) activates the plasma membrane (PM) channel Orai1 in order to mediate store …
(STIM1) activates the plasma membrane (PM) channel Orai1 in order to mediate store …
STIM1 translocation to the plasma membrane enhances intestinal epithelial restitution by inducing TRPC1-mediated Ca2+ signaling after wounding
JN Rao, N Rathor, T Zou, L Liu, L Xiao… - … of Physiology-Cell …, 2010 - journals.physiology.org
Early epithelial restitution is an important repair modality in the gut mucosa and occurs as a
consequence of epithelial cell migration. Canonical transient receptor potential-1 (TRPC1) …
consequence of epithelial cell migration. Canonical transient receptor potential-1 (TRPC1) …
Elevated Orai1 and STIM1 expressions upregulate MACC1 expression to promote tumor cell proliferation, metabolism, migration, and invasion in human gastric …
J Xia, H Wang, H Huang, L Sun, S Dong, N Huang… - Cancer letters, 2016 - Elsevier
ORAI calcium release-activated calcium modulator 1 (Orai1)-and stromal interacting
molecule 1 (STIM1)-mediated store-operated Ca 2+ entry (SOCE) have been increasingly …
molecule 1 (STIM1)-mediated store-operated Ca 2+ entry (SOCE) have been increasingly …
Stromal interaction molecule 1 (STIM1) silencing inhibits tumor growth and promotes cell cycle arrest and apoptosis in hypopharyngeal carcinoma
Y Sun, X Cui, J Wang, S Wu, Y Bai, Y Wang, B Wang… - Medical Oncology, 2015 - Springer
As an important pathway maintaining the balance of intracellular calcium (Ca 2+), store-
operated Ca 2+ entry (SOCE) is critical for cellular functions. Stromal interaction molecule 1 …
operated Ca 2+ entry (SOCE) is critical for cellular functions. Stromal interaction molecule 1 …
Store‐operated calcium entry controls innate and adaptive immune cell function in inflammatory bowel disease
M Letizia, YH Wang, U Kaufmann… - EMBO Molecular …, 2022 - embopress.org
Inflammatory bowel disease (IBD) is characterized by dysregulated intestinal immune
responses. Using mass cytometry (CyTOF) to analyze the immune cell composition in the …
responses. Using mass cytometry (CyTOF) to analyze the immune cell composition in the …