Organs used for transplantation are usually derived from heart-beating brain dead donors.
However, brain death is known to have negative effects on donor organ quality, previously …

Objectives Experimental animal models of brain death that mimic human conditions may be
useful for investigating novel strategies that increase quality and quantity of organs for …

Background. The relatively few studies that have examined the systemic events after brain
death have primarily involved large animals. For more precise definition of the physiology of …

Background This study was designed to establish a validated canine brain death model. Ten
consecutive dogs were studied to investigate the effects of brain death on hemodynamic …

INTRODUCTION: An animal model that imitates human conditions might be useful not only
to monitor pathomechanisms of brain death and biochemical cascades but also to …

The need for cadaveric organs for transplantation is increasing. To decrease the shortage of
organs, identification of potential donors and conditioning of these donors must improve. We …

Background. Marginal donors exposed to the full array of effects induced by brain death are
characterized by low success rates after transplantation. This study examined whether …

Background. Eighty percent of donor organs come from donors who have suffered brain
trauma (brain-dead donors). This unphysiological state alters the hemodynamic and …

Background. At present, organ transplantation is the most efficient treatment of end-stage
failure of various organs, including the heart, lungs, pancreas, intestines, kidney, and liver …

In contrast to the marked improvement in early results, the rate of long-term survival of solid-
organ allografts has improved only slowly over the last few years despite the introduction of …