Targeting the Wnt/β-catenin signaling pathway as a potential therapeutic strategy in renal tubulointerstitial fibrosis
SS Li, Q Sun, MR Hua, P Suo, JR Chen… - Frontiers in …, 2021 - frontiersin.org
The Wnt/β-catenin signaling pathway plays important roles in embryonic development and
tissue homeostasis. Wnt signaling is induced, and β-catenin is activated, associated with the …
tissue homeostasis. Wnt signaling is induced, and β-catenin is activated, associated with the …
[HTML][HTML] Wnt/β-catenin signaling and kidney fibrosis
Wnt/β-catenin signaling is an evolutionarily conserved, highly complex, key developmental
pathway that regulates cell fate, organ development, tissue homeostasis, as well as injury …
pathway that regulates cell fate, organ development, tissue homeostasis, as well as injury …
New insights into the role and mechanism of Wnt/β‐catenin signalling in kidney fibrosis
Y Zuo, Y Liu - Nephrology, 2018 - Wiley Online Library
Wnt/β‐catenin is an evolutionarily conserved, developmental signalling pathway that
regulates embryogenesis, injury repair and pathogenesis of human diseases. Dysregulated …
regulates embryogenesis, injury repair and pathogenesis of human diseases. Dysregulated …
Wnt/β-catenin signaling: a novel target for therapeutic intervention of fibrotic kidney disease
I Hwang, E Seo, H Ha - Archives of pharmacal research, 2009 - Springer
Fibrosis of epithelial parenchymal organs and end-stage organ failure, the final common
pathway of many progressive chronic diseases including chronic kidney disease, continue …
pathway of many progressive chronic diseases including chronic kidney disease, continue …
Wnt/β-catenin signaling promotes renal interstitial fibrosis
W He, C Dai, Y Li, G Zeng, SP Monga… - Journal of the American …, 2009 - journals.lww.com
Wnts compose a family of signaling proteins that play an essential role in kidney
development, but their expression in adult kidney is thought to be silenced. Here, we …
development, but their expression in adult kidney is thought to be silenced. Here, we …
Molecular targets for treatment of kidney fibrosis
PY Chuang, MC Menon, JC He - Journal of molecular medicine, 2013 - Springer
Renal fibrosis is the culmination of processes driven by signaling pathways involving
transforming growth factor-β family of cytokines, connective-tissue growth factor, nuclear …
transforming growth factor-β family of cytokines, connective-tissue growth factor, nuclear …
Emerging therapeutic strategies for attenuating tubular EMT and kidney fibrosis by targeting Wnt/β-catenin signaling
L Hu, M Ding, W He - Frontiers in pharmacology, 2022 - frontiersin.org
Epithelial-mesenchymal transition (EMT) is defined as a process in which differentiated
epithelial cells undergo phenotypic transformation into myofibroblasts capable of producing …
epithelial cells undergo phenotypic transformation into myofibroblasts capable of producing …
Kidney tubular β-catenin signaling controls interstitial fibroblast fate via epithelial-mesenchymal communication
Activation of β-catenin, the principal mediator of canonical Wnt signaling, is a common
pathologic finding in a wide variety of chronic kidney diseases (CKD). While β-catenin is …
pathologic finding in a wide variety of chronic kidney diseases (CKD). While β-catenin is …
Wnt/β-catenin–promoted macrophage alternative activation contributes to kidney fibrosis
The Wnt/β-catenin pathway is crucial in normal development and throughout life, but
aberrant activation of this pathway has been linked to kidney fibrosis, although the …
aberrant activation of this pathway has been linked to kidney fibrosis, although the …
Wnt signaling in kidney development and disease
Y Wang, CJ Zhou, Y Liu - Progress in molecular biology and translational …, 2018 - Elsevier
Wnt signal cascade is an evolutionarily conserved, developmental pathway that regulates
embryogenesis, injury repair, and pathogenesis of human diseases. It is well established …
embryogenesis, injury repair, and pathogenesis of human diseases. It is well established …