The number of primordial follicles in the ovarian reserve is an important determinant of the
length of the ovarian lifespan, and therefore the fertility of an individual. This reserve …

The creation of the pool of follicles available for selection and ovulation is a multi-faceted,
tightly regulated process that spans the period from embryonic development through to the …

The mammalian ovarian reserve is comprised of a finite pool of primordial follicles,
representing the lifetime reproductive capacity of females. In most mammals, the reserve is …

The female germline comprises a reserve population of primordial (non-growing) follicles
containing diplotene oocytes arrested in the first meiotic prophase. By convention, the …

The functional life span of the ovaries is dictated in large part by the number of oocytes
present, a number that is known to decline precipitously during both fetal development and …

The growing follicles develop from a reserve of primordial follicles constituted early in life.
From this pre-established reserve, a second ovarian reserve is formed, which consists of …

The adult mammalian ovary is devoid of definitive germline stem cells. As such, female
reproductive senescence largely results from the depletion of a finite ovarian follicle pool …

Proliferation and partial meiotic maturation of germ cells in fetal ovaries is believed to
establish a finite, non-renewable pool of primordial follicles at birth. The supply of primordial …

Mammalian ovaries consist of follicles as basic functional units. The total number of ovarian
follicles is determined early in life, and the depletion of this pool leads to reproductive …

OBJECTIVE: To assess directly the dynamics of the formation of the ovarian reserve in the
normal human ovary by evaluating the total number of follicles in developing ovaries when …