Podocytes are highly specialized cells of the kidney glomerulus that wrap around capillaries
and that neighbor cells of the Bowman's capsule. When it comes to glomerular filtration …

The podocyte is a key component of the glomerular filtration barrier. Podocyte dysfunction is
central to the underlying pathophysiology of many common glomerular diseases, including …

Background: Podocyte biology is a developing science that promises to help improve
understanding of the mechanistic nature of multiple diseases associated with proteinuria …

Glomerular visceral epithelial cells, also known as podocytes, are highly specialized
epithelial cells that cover the outer layer of the glomerular basement membrane. Podocytes …

Glomerular podocytes are highly specialized cells with a complex cytoarchitecture. Their
most prominent features are interdigitated foot processes with filtration slits in between …

The explosion of podocyte biology during the last decade has radically altered our views on
the pathophysiologic process of proteinuria, glomerular disease, and progressive kidney …

Severe defects in the glomerular filtration barrier result in nephrotic syndrome, which is
characterized by massive proteinuria. The podocyte, a specialized epithelial cell with …

Disturbances in many different molecular pathways and interactions can lead to the same
clinical end points of proteinuria and end-stage renal disease. Proteinuria is often …

Proteinuric chronic kidney disease (CKD), once a rare affliction believed to be mainly
caused by genetic mutations, has become a global pandemic that severely diminishes the …

Human genetic and in vivo studies have helped to define the critical importance of
podocytes for kidney function in health and disease. However, as in any other research …