[HTML][HTML] Cell competition and the regulation of protein homeostasis

S Krishnan, PK Paul, TA Rodriguez - Current Opinion in Cell Biology, 2024 - Elsevier
The process of embryonic development involves remarkable cellular plasticity, which
governs the coordination between cells necessary to build an organism. One role of this …

[PDF][PDF] Differences in mitochondrial activity trigger cell competition during early mouse development

A Lima, G Lubatti, J Burgstaller, D Hu, A Green… - bioRxiv, 2020 - researchgate.net
Cell competition is emerging as a quality control mechanism that eliminates unfit cells in a
wide range of settings from development to the adult. However, the nature of the cells …

Cell wars: regulation of cell survival and proliferation by cell competition

S Vivarelli, L Wagstaff, E Piddini - Essays in biochemistry, 2012 - portlandpress.com
During cell competition fitter cells take over the tissue at the expense of viable, but less fit,
cells, which are eliminated by induction of apoptosis or senescence. This probably acts as a …

Cell competition acts as a purifying selection to eliminate cells with mitochondrial defects during early mouse development

A Lima, G Lubatti, J Burgstaller, D Hu, AP Green… - Nature …, 2021 - nature.com
Cell competition is emerging as a quality-control mechanism that eliminates unfit cells in a
wide range of settings from development to the adult. However, the nature of the cells …

Cell competition in vertebrates—A key machinery for tissue homeostasis

T Maruyama, Y Fujita - Current Opinion in Genetics & Development, 2022 - Elsevier
Cell competition is a process by which cells with different properties compete with each
other for survival and space, and consequently suboptimal/abnormal cells are often …

Cell competition: how to eliminate your neighbours

M Amoyel, EA Bach - Development, 2014 - journals.biologists.com
A conventional view of development is that cells cooperate to build an organism. However,
based on studies of Drosophila, it has been known for years that viable cells can be …

[HTML][HTML] Cell competition and the regulative nature of early mammalian development

J Nichols, A Lima, TA Rodríguez - Cell Stem Cell, 2022 - cell.com
The mammalian embryo exhibits a remarkable plasticity that allows it to correct for the
presence of aberrant cells, adjust its growth so that its size is in accordance with its …

Cell competition in development, homeostasis and cancer

SM van Neerven, L Vermeulen - Nature Reviews Molecular Cell …, 2023 - nature.com
Organ development and homeostasis involve dynamic interactions between individual cells
that collectively regulate tissue architecture and function. To ensure the highest tissue …

Evolution and cell physiology. 2. The evolution of cell signaling: from mitochondria to Metazoa

NW Blackstone - American Journal of Physiology-Cell …, 2013 - journals.physiology.org
The history of life is a history of levels-of-selection transitions. Each transition requires
mechanisms that mediate conflict among the lower-level units. In the origins of multicellular …

Cell competition: emerging signaling and unsolved questions

R Nagata, T Igaki - FEBS letters, 2024 - Wiley Online Library
Multicellular communities have an intrinsic mechanism that optimizes their structure and
function via cell–cell communication. One of the driving forces for such self‐organization of …