Clostridium botulinum C3 exoenzyme (C3) selectively inactivates RhoA/B/C GTPases by
ADP-ribosylation. Based on this substrate specificity C3 is a well-established tool in cell …

The Clostridium botulinum C3 exoenzyme selectively ADP-ribosylates low molecular weight
GTP-binding proteins RhoA, B and C. This covalent modification inhibits Rho signaling …

Clostridium botulinum C3 is the prototype of C3-like ADP-ribosyltransferases that selectively
ADP-ribosylate the small GTP-binding proteins RhoA/B/C and inhibit their downstream …

C3 from Clostridium botulinum (C3) specifically modifies Rho GTPases RhoA, RhoB, and
RhoC by mono-ADP-ribosylation. The confined substrate profile of C3 is the basis for its use …

The type III intermediate filament protein vimentin was recently identified to mediate binding
and uptake of Clostridium botulinum C3 exoenzyme (C3bot) in two cell lines. Here, we used …

C3 exoenzyme from Clostridium botulinum is the prototype of bacterial ADP-
ribosyltransferases, which selectively modifies the Rho isoforms RhoA, RhoB and RhoC by …

C3-like exoenzymes are produced by various microorganism including Clostridium
botulinum (C3bot), Bacillus cereus and Staphylococcus aureus. C3bot is the prototype of C3 …

The C3 transferases from Clostridium botulinum (C3bot) and Clostridium limosum (C3lim)
mono‐ADP‐ribosylate and thereby inactivate RhoA,‐B and‐C of eukaryotic cells. Due to …

The Rho ADP-ribosylating C3 exoenzyme (C3bot) is a bacterial protein toxin devoid of a cell-
binding or-translocation domain. Nevertheless, C3 can efficiently enter intact cells, including …

Clostridium botulinum C3 transferase (C3bot) ADP‐ribosylates rho proteins to change
cellular functions in a variety of cell types including astrocytes and neurons. The …