The small intestine has a high rate of cell turnover under homeostatic conditions, and this
increases further in response to infection or damage. Epithelial cells mostly die by apoptosis …

Usually, the massive elimination of cells under steady-state conditions occurs by apoptosis,
which is also acknowledged to explain the loss of enterocytes in the small intestine of celiac …

Intestinal epithelial cells have a rapid turnover, being rapidly renewed by newly
differentiated enterocytes, balanced by massive and constant removal of damaged cells by …

The maintenance of mucosal barrier equilibrium in the intestine requires a delicate and
dynamic balance between enterocyte loss by apoptosis and the generation of new cells by …

The intestinal tract is a site of intense immune cell activity that is poised to mount an effective
response against a pathogen and yet maintain tolerance toward commensal bacteria and …

Celiac disease (CD) is a complex immune-mediated chronic disease characterized by a
consistent inflammation of the gastrointestinal tract induced by gluten intake in genetically …

BACKGROUND Lamina propria (LPLs) and intraepithelial (IELs) lymphocytes are markedly
increased in coeliac mucosa, and are thought to play a crucial role in the generation of …

Celiac disease (CD) is a gluten sensitive enteropathy characterized by a marked infiltration
of the mucosa with immune cells, over-production of inflammatory cytokines and epithelial …

The intestinal epithelium has one of the highest rates of cellular turnover in a process that is
tightly regulated. As the transit-amplifying progenitors of the intestinal epithelium generate …

Coeliac disease is an inflammatory disorder with autoimmune features that is characterized
by destruction of the intestinal epithelium and remodelling of the intestinal mucosa following …