Human epithelial stem cells (ESCs) are characterized by long‐term regenerative properties,
much dependent on the tissue of origin and varying during their lifespan. We analysed such …

Adult stem cells exist in most mammalian organs and tissues and are indispensable for
normal tissue homeostasis and repair. In most tissues, there is an age-related decline in …

" There is growing evidence that adult stem cells age. This process can result in alterations
in the number and function of stem cells, leading to distinct phenotypic outcomes in different …

Skin is the largest organ in human body, harboring a plethora of cell types and serving as
the organismal barrier. Skin aging such as wrinkling and hair graying is graphically …

Cellular senescence is a specialized form of growth arrest, confined to mitotic cells, induced
by various stressful stimuli and characterized by a permanent growth arrest, resistance to …

Human epithelial cells undergo morphological and molecular changes leading to terminal
differentiation and replicative senescence after a finite number of cell divisions during serial …

The recent advances in deciphering the human genome allow us to understand and
evaluate the mechanisms of human genome age-associated transformations, which are …

Stem cells have self-renewal ability and multi-directional differentiation potential. They have
tissue repair capabilities and are essential for maintaining the tissue homeostasis. The …

Senescence is a state of enduring growth arrest triggered by sublethal cell damage. Given
that senescent cells actively secrete proinflammatory and matrix-remodeling proteins, their …

Adult stem cells have taken center stage in current research related to regenerative
medicine and pharmacogenomic studies seeking new therapeutic interventions. As we learn …