Dl-3-n-butylphthalide exerts neuroprotective effects by modulating hypoxia-inducible factor 1-alpha ubiquitination to attenuate oxidative stress-induced apoptosis
S Li, J Zhao, Y Xi, J Ren, Y Zhu, Y Lu… - Neural Regeneration …, 2023 - journals.lww.com
Abstract Dl-3-n-butylphthalide is used to treat mild and moderate acute ischemic stroke.
However, the precise underlying mechanism requires further investigation. In this study, we …
However, the precise underlying mechanism requires further investigation. In this study, we …
Dl-3-n-butylphthalide attenuates hypoxic-ischemic brain injury through inhibiting endoplasmic reticulum stress-induced cell apoptosis and alleviating blood-brain …
M Fang, J Yuan, S Jiang, Y Hu, S Pan, J Zhu, X Fu… - Brain research, 2020 - Elsevier
Abstract Dl-3-n-butylphthalide (NBP) has been demonstrated to exert neuroprotective effects
in experimental models and human patients. This study was performed to assess the …
in experimental models and human patients. This study was performed to assess the …
Hypoxia inducible factor-1alpha mediates protection of DL-3-n-butylphthalide in brain microvascular endothelial cells against oxygen glucose deprivation-induced …
W Yang, L Li, R Huang, Z Pei, S Liao… - Neural regeneration …, 2012 - journals.lww.com
Studies have demonstrated that DL-3-n-butylphthalide can significantly alleviate oxygen
glucose deprivation-induced injury of human umbilical vein endothelial cells at least partly …
glucose deprivation-induced injury of human umbilical vein endothelial cells at least partly …
DL-3-n-butylphthalide prevents neuronal cell death after focal cerebral ischemia in mice via the JNK pathway
dl-3-n-Butylphthalide (NBP) has shown cytoprotective effects in animal models of stroke and
has passed clinical trials as a therapeutic drug for stroke in China. Hence, as a potential …
has passed clinical trials as a therapeutic drug for stroke in China. Hence, as a potential …
DL-3-n-butylphthalide induced neuroprotection, regenerative repair, functional recovery and psychological benefits following traumatic brain injury in mice
Previous investigations suggest that DL-3-n-butylphthalide (NBP) is a promising
multifaceted drug for the treatment of stroke. It is not clear whether NBP can treat traumatic …
multifaceted drug for the treatment of stroke. It is not clear whether NBP can treat traumatic …
[HTML][HTML] Dl-3-n-butylphthalide reduces neurovascular inflammation and ischemic brain injury in mice
Abstract Dl-3-n-butylphthalide (NBP) is a synthetic compound that has been approved for
the treatment of ischemic stroke in China. The mechanisms underlying the treatment efficacy …
the treatment of ischemic stroke in China. The mechanisms underlying the treatment efficacy …
DL-3-n-butylphthalide protects endothelial cells against oxidative/nitrosative stress, mitochondrial damage and subsequent cell death after oxygen glucose …
L Li, B Zhang, Y Tao, Y Wang, H Wei, J Zhao, R Huang… - Brain research, 2009 - Elsevier
dl-3-n-butylphthalide (NBP) has been used for stroke treatment in China for years. Recently,
we found that NBP can reduce the incidence of stroke and have protective action on …
we found that NBP can reduce the incidence of stroke and have protective action on …
Neuroprotective mechanisms of 3‑n‑butylphthalide in neurodegenerative diseases
R Luo, R Wangqin, L Zhu, W Bi - Biomedical Reports, 2019 - spandidos-publications.com
Abstract Since 3‑n‑butylphthalide (NBP) was approved by the China Food and Drug
Administration for the treatment of acute ischemia stroke in 2002, a number of studies have …
Administration for the treatment of acute ischemia stroke in 2002, a number of studies have …
l-3-n-Butylphthalide Activates Akt/mTOR Signaling, Inhibits Neuronal Apoptosis and Autophagy and Improves Cognitive Impairment in Mice with Repeated Cerebral …
J Xu, Y Huai, N Meng, Y Dong, Z Liu, Q Qi, M Hu… - Neurochemical …, 2017 - Springer
Abstract l-3-n-Butylphthalide (l-NBP) exerts neuroprotective effects in animal models of
cerebral ischemia, but its potential benefits in repeated cerebral ischemia–reperfusion …
cerebral ischemia, but its potential benefits in repeated cerebral ischemia–reperfusion …
5d, a novel analogue of 3-n-butylphthalide, protects brains against nervous injury induced by ischemia/reperfusion through Akt/Nrf2/NOX4 signaling pathway
J Ling, H Ji, X Wang, Y Zhang, C Zhang, H Song, J Li… - RSC Advances, 2015 - pubs.rsc.org
Oxidative stress has been shown to play a vital role in the pathogenesis of the
ischemia/reperfusion (I/R) and may represent a target for treatment. 3-Butyl-2 …
ischemia/reperfusion (I/R) and may represent a target for treatment. 3-Butyl-2 …