Structure, gating, and regulation of the CFTR anion channel
The cystic fibrosis transmembrane conductance regulator (CFTR) belongs to the ATP
binding cassette (ABC) transporter superfamily but functions as an anion channel crucial for …
binding cassette (ABC) transporter superfamily but functions as an anion channel crucial for …
CFTR structure and cystic fibrosis
N Cant, N Pollock, RC Ford - The international journal of biochemistry & …, 2014 - Elsevier
CFTR (cystic fibrosis transmembrane conductance regulator) is a member of the ATP-
binding cassette family of membrane proteins. Although almost all members of this family …
binding cassette family of membrane proteins. Although almost all members of this family …
Structural mechanisms of CFTR function and dysfunction
Cystic fibrosis (CF) transmembrane conductance regulator (CFTR) chloride channel plays a
critical role in regulating transepithelial movement of water and electrolyte in exocrine …
critical role in regulating transepithelial movement of water and electrolyte in exocrine …
[HTML][HTML] Molecular structure of the human CFTR ion channel
The cystic fibrosis transmembrane conductance regulator (CFTR) is an ATP-binding
cassette (ABC) transporter that uniquely functions as an ion channel. Here, we present a 3.9 …
cassette (ABC) transporter that uniquely functions as an ion channel. Here, we present a 3.9 …
[HTML][HTML] Atomic structure of the cystic fibrosis transmembrane conductance regulator
The cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel
evolved from the ATP-binding cassette (ABC) transporter family. In this study, we determined …
evolved from the ATP-binding cassette (ABC) transporter family. In this study, we determined …
Gating of the CFTR Cl− channel by ATP‐driven nucleotide‐binding domain dimerisation
TC Hwang, DN Sheppard - The Journal of physiology, 2009 - Wiley Online Library
The cystic fibrosis transmembrane conductance regulator (CFTR) plays a fundamental role
in fluid and electrolyte transport across epithelial tissues. Based on its structure, function and …
in fluid and electrolyte transport across epithelial tissues. Based on its structure, function and …
Structure and function of the CFTR chloride channel
DN Sheppard, MJ Welsh - Physiological reviews, 1999 - journals.physiology.org
Sheppard, David N., and Michael J. Welsh. Structure and Function of the CFTR Chloride
Channel. Physiol. Rev. 79, Suppl.: S23–S45, 1999.—The cystic fibrosis transmembrane …
Channel. Physiol. Rev. 79, Suppl.: S23–S45, 1999.—The cystic fibrosis transmembrane …
ATP-independent CFTR channel gating and allosteric modulation by phosphorylation
Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance
regulator (CFTR) channel, an ATP binding cassette (ABC) transporter. CFTR gating is linked …
regulator (CFTR) channel, an ATP binding cassette (ABC) transporter. CFTR gating is linked …
[HTML][HTML] Conformational changes of CFTR upon phosphorylation and ATP binding
The cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel
evolved from an ATP-binding cassette transporter. CFTR channel gating is strictly coupled to …
evolved from an ATP-binding cassette transporter. CFTR channel gating is strictly coupled to …
Assembly of functional CFTR chloride channels
JR Riordan - Annu. Rev. Physiol., 2005 - annualreviews.org
▪ Abstract The assembly of the cystic fibrosis transmembrane regulator (CFTR) chloride
channel is of interest from the broad perspective of understanding how ion channels and …
channel is of interest from the broad perspective of understanding how ion channels and …