The absorption of glucose is electrogenic in the small intestinal epithelium. The major route
for the transport of dietary glucose from intestinal lumen into enterocytes is the Na+/glucose …

SGLT1 (Na+/glucose co-transporter 1) transports the dietary sugars, d-glucose and d-
galactose, from the lumen of the intestine into enterocytes. SGLT1 regulation has important …

We have proposed a model of intestinal glucose absorption in which transport by SGLT1
induces rapid insertion and activation of GLUT2 in the apical membrane by a PKC βII …

Absorption of monosaccharides is mainly mediated by Na+-d-glucose cotransporter SGLT1
and the facititative transporters GLUT2 and GLUT5. SGLT1 and GLUT2 are relevant for …

The worldwide prevalence of metabolic diseases such as obesity, metabolic syndrome and
type 2 diabetes shows an upward trend in recent decades. A characteristic feature of these …

Glucose is an important nutrient for mammalian cells. It is a major source of energy, as well
as a substrate for macromolecules including glycoproteins, proteoglycans, glycolipids and …

Intestinal Na+-coupled glucose transporter SGLT1 determines the rate of glucose transport,
which in turn influences glucose-induced insulin release and development of obesity. The …

Sugar consumption and subsequent sugar metabolism are known to regulate the
expression of genes involved in intestinal sugar absorption and delivery. Here we …

The Na+-dependent glucose transporter SGLT1 and the facilitated fructose transporter
GLUT5 absorb sugars from the intestinal lumen across the brush-border membrane into the …

ABSTRACT Na+/glucose cotransporters (SGLTs) are expressed in the small intestine and
the proximal renal tubule, where they play a central role in the absorption of glucose and …