Perinatal asphyxia resulting in hypoxic–ischemic (HI) brain injury is one of the most common
causes of neonatal morbidity and mortality, with nearly 1 million neonatal deaths per year. 1 …

Hypoxia-ischemia (HI) before or at birth is the single most common cause of perinatal brain
injury in term infants, affecting approximately 1.5 to 3/1000 live births annually in highincome …

Perinatal asphyxia remains a frequent cause of cerebral palsy, mental retardation, learning
disability, epilepsy, and death. 1 The worldwide burden is 4 million newborns every year, of …

Neonatal encephalopathy (NE) that purportedly arises from hypoxia‐ischemia is labeled
hypoxic‐ischemic encephalopathy (HIE). Perinatal asphyxia is a clinical syndrome involving …

Interruption of blood flow and gas exchange to the fetus in the perinatal period, known as
perinatal asphyxia, can, if significant, trigger a cascade of neuronal injury, leading on to …

Perinatal asphyxia occurs still with great incidence whenever delivery is prolonged, despite
improvements in perinatal care. After asphyxia, infants can suffer from short-to long-term …

Hypoxic-ischemic brain injury remains a leading cause of mortality and morbidity in
neonates. The inflammatory response, which is characterized in part by activation of local …

This article summarizes the recent medical literature regarding perinatal asphyxia with
respect to timing and mechanisms of injury for neonates who were clinically diagnosed with …

BACKGROUND: The fetal brain is vulnerable to severe and sustained hypoxia during and
after birth, which can lead to hypoxic-ischemic encephalopathy (HIE). HIE is characterized …

Objectives To identify biomarkers for neuronal injury and outcome in perinatal asphyxia.
Methods This prospective cohort study was done in authors' level III NICU involving 80 …