Under various pathological conditions, including thrombosis and inflammation, extracellular
nucleotide levels may increase because of both active release and passive leakage from …

Inflammation is a complex pathophysiological process underlying many clinical conditions.
Platelets contribute to the thrombo‐inflammatory response. Platelet P2Y12 receptors amplify …

Purinergic G-protein-coupled receptors are ancient and the most abundant group of G-
protein-coupled receptors (GPCRs). The wide distribution of purinergic receptors in the …

The P2Y12 receptor is a key player in platelet activation and a major target for antithrombotic
drugs. The beneficial effects of P2Y12 receptor antagonists might, however, not be restricted …

Platelets play an important role not only during thrombosis, but also in modulating immune
responses through their interaction with immune cells and by releasing inflammatory …

Background—Atherosclerosis is an inflammatory disease, and extracellular nucleotides are
one of the factors possibly involved in vascular inflammation. The P2Y1 receptor for …

Extracellular nucleotides are ubiquitous signalling molecules, acting via the P2 class of
surface receptors. Platelets express three P2 receptor subtypes, ADP-dependent P2Y1 and …

Purinergic signaling involves the activation of cell surface P1 and P2 receptors by
extracellular nucleosides and nucleotides such as adenosine and adenosine triphosphate …

The platelet surface membrane possesses three P2 receptors activated by extracellular
adenosine nucleotides; one member of the ionotropic receptor family (P2X1) and two …

Activation of P2Y1 and P2Y12 receptors, through secreted ADP that is stimulated by
agonists such as thrombin, thromboxane and collagen, is a major mechanism of platelet …