The role of DNA methylation in the regulation of catabolic genes such as MMP13 and IL1B,
which have sparse CpG islands, is poorly understood in the context of musculoskeletal …

Osteoarthritis is a degenerative joint disease characterized by a progressive and irreversible
loss of the articular cartilage, due in main part to the cleavage of type II collagen within the …

Objective Human articular chondrocytes do not express COL10A1 and do not undergo
hypertrophy except in close vicinity to subchondral bone. In contrast, chondrocytes produced …

Objective To determine whether changes in the DNA methylation status in the promoter
region of the gene encoding interleukin‐1β (IL‐1β) account for expression of IL1B …

Osteoarthritic chondrocytes secrete matrix metalloproteinase-13 (MMP-13) in response to
interleukin-1 (IL-1), causing digestion of type II collagen in cartilage. Using chondrocytic …

Objective To determine whether altered IL8 methylation status is associated with increased
expression of IL8 in human osteoarthritic (OA) chondrocytes. Methods IL8 expression levels …

Objective Human synovium–derived mesenchymal stem cells (MSCs) can efficiently
differentiate into mature chondrocytes. It has been suggested that DNA methylation is one …

Objective To investigate whether the changes in collagen gene expression in osteoarthritic
(OA) human chondrocytes are associated with changes in the DNA methylation status in the …

Elucidating the regulatory mechanism for tissue-specific gene expression is key to
understanding the differentiation process. The chondromodulin-I gene (ChM-I) is a cartilage …

Abstract Matrix metalloproteinase 3 (MMP3) is well known as a secretory endopeptidase that
degrades extracellular matrices. Recent reports indicated the presence of MMPs in the …