[PDF][PDF] Gram-negative bacteria resist antimicrobial agents by a DzrR-mediated envelope stress

Z Liang, Q Lin, Q Wang, L Huang, H Liu, Z Shi, Z Cui… - 2023 - bmcbiol.biomedcentral.com
Abstract Background Envelope stress responses (ESRs) are critical for adaptive resistance
of Gram‑negative bacteria to envelope‑targeting antimicrobial agents. However, ESRs are …

Gram-negative bacteria resist antimicrobial agents by a DzrR-mediated envelope stress response

Z Liang, Q Lin, Q Wang, L Huang, H Liu, Z Shi, Z Cui… - BMC biology, 2023 - Springer
Abstract Background Envelope stress responses (ESRs) are critical for adaptive resistance
of Gram-negative bacteria to envelope-targeting antimicrobial agents. However, ESRs are …

RND Efflux Pump Induction: A Crucial Network Unveiling Adaptive Antibiotic Resistance Mechanisms of Gram-Negative Bacteria

M Novelli, JM Bolla - Antibiotics, 2024 - mdpi.com
The rise of multi-drug-resistant (MDR) pathogenic bacteria presents a grave challenge to
global public health, with antimicrobial resistance ranking as the third leading cause of …

A substrate-activated efflux pump, DesABC, confers zeamine resistance to Dickeya zeae

Z Liang, L Huang, F He, X Zhou, Z Shi, J Zhou, Y Chen… - MBio, 2019 - Am Soc Microbiol
Zeamines are a family of polyamino phytotoxins produced by Dickeya zeae EC1. These
phytotoxins are also potent antibiotics against a range of microorganisms. To understand …

Molecular determinant deciphering of MIC-guided RND efflux substrates in E. coli

J Revol-Tissot, G Boyer, S Alibert - Frontiers in Drug Discovery, 2024 - frontiersin.org
Antimicrobial resistance poses an urgent and formidable global public health threat. The
escalation of bacterial multidrug resistance to antibiotics has the potential to become a …

Comprehensive analysis of resistance-nodulation-cell division superfamily (RND) efflux pumps from Serratia marcescens, Db10

S Toba, Y Minato, Y Kondo, K Hoshikawa… - Scientific reports, 2019 - nature.com
We investigated the role of the resistance-nodulation-cell division superfamily (RND) efflux
system on intrinsic multidrug resistance in Serratia marcescens. We identified eight putative …

RND efflux pumps in Gram-negative bacteria; regulation, structure and role in antibiotic resistance

AL Colclough, I Alav, EE Whittle, HL Pugh… - Future …, 2020 - Taylor & Francis
Rresistance-nodulation-division (RND) efflux pumps in Gram-negative bacteria remove
multiple, structurally distinct classes of antimicrobials from inside bacterial cells therefore …

Characterization of the Arn lipopolysaccharide modification system essential for zeamine resistance unveils its new roles in Dickeya oryzae physiology and virulence

Z Liang, L Huang, H Liu, Y Zheng, J Feng… - Molecular Plant …, 2023 - Wiley Online Library
The zeamines produced by Dickeya oryzae are potent polyamine antibiotics and phytotoxins
that are essential for bacterial virulence. We recently showed that the RND efflux pump …

The Two-Component System RstA/RstB Regulates Expression of Multiple Efflux Pumps and Influences Anaerobic Nitrate Respiration in Pseudomonas fluorescens

L Di-Yin, H Jian-Ting, Z Meng-Yuan, Y Xu… - …, 2021 - search.proquest.com
Multidrug resistance (MDR) efflux pumps are involved in bacterial intrinsic resistance to
multiple antimicrobials. Expression of MDR efflux pumps can be either constitutive or …

The two-component system RstA/RstB regulates expression of multiple efflux pumps and influences anaerobic nitrate respiration in Pseudomonas fluorescens

DY Li, JT Han, MY Zhang, X Yan, N Zhang, H Ge… - Msystems, 2021 - Am Soc Microbiol
Multidrug resistance (MDR) efflux pumps are involved in bacterial intrinsic resistance to
multiple antimicrobials. Expression of MDR efflux pumps can be either constitutive or …