Addiction is a complex disease that impacts millions of people around the world. Clinically,
addiction is formalized as substance use disorder (SUD), with three primary symptom …

Advances in neuroscience identified addiction as a chronic brain disease with strong
genetic, neurodevelopmental, and sociocultural components. We here discuss the circuit …

Recent animal research on substance-use disorders (SUDs) has emphasized learning
models and the identification of 'addiction-prone'animals. Meanwhile, basic neuroscientific …

The striatal dopamine system has long been studied in the context of reward learning,
motivation, and movement. Given the prominent role dopamine plays in a variety of adaptive …

Drug addiction is a chronic relapsing disorder, and a significant amount of research has
been devoted to understand the factors that contribute to the development, loss of control …

This review is an introduction to addiction, the reward circuitry, and laboratory addiction
models. Addiction is a chronic disease hallmarked by a state of compulsive drug seeking …

Impulsive–compulsive disorders such as pathological gambling, hypersexuality, compulsive
eating, and shopping are side effects of the dopaminergic therapy for Parkinson's disease …

It is widely believed that substance use disorder (SUD) results from both pre-alterations
(vulnerability) and/or post-alterations (drug effects) on cortico-striatal circuits. These circuits …

Addictive substances are known to increase dopaminergic signaling in the
mesocorticolimbic system. The origin of this dopamine (DA) signaling originates in the …

Addiction is characterized by a compulsive pattern of drug seeking and consumption and a
high risk of relapse after withdrawal that are thought to result from persistent adaptations …