[HTML][HTML] Roles of calcitonin gene-related peptide in the skin, and other physiological and pathophysiological functions

YJ Kim, RD Granstein - Brain, Behavior, & Immunity-Health, 2021 - Elsevier
Skin immunity is regulated by many mediator molecules. One is the neuropeptide calcitonin
gene-related peptide (CGRP). CGRP has roles in regulating the function of components of …

Calcitonin gene‐related peptide: key regulator of cutaneous immunity

RD Granstein, JA Wagner, LL Stohl… - Acta physiologica, 2015 - Wiley Online Library
Calcitonin gene‐related peptide (CGRP) has been viewed as a neuropeptide and
vasodilator. However, CGRP is more appropriately thought of as a pleiotropic signalling …

Calcitonin Gene-Related Peptide Inhibits Proliferation and Antigen Presentation by Human Peripheral Blood Mononuclear Cells: Effects on B7, Interleukin 10, and …

FE Fox, M Kubin, M Cassin, Z Niu, J Hosoi… - Journal of investigative …, 1997 - Elsevier
CGRP is a neuropeptide that has previously been described to possess immunosuppressive
activities. CGRP is released from peripheral nerves that, in the skin, are in close physical …

Calcitonin gene-related peptide is an important regulator of cutaneous immunity: effect on dendritic cell and T cell functions

N Mikami, H Matsushita, T Kato… - The Journal of …, 2011 - journals.aai.org
Some cutaneous inflammations are induced by percutaneous exposure to foreign Ags, and
many chemical mediators regulate this inflammation process. One of these mediators …

Calcitonin gene-related peptide is a key neurotransmitter in the neuro-immune axis

BM Assas, JI Pennock, JA Miyan - Frontiers in neuroscience, 2014 - frontiersin.org
The question of how the neural and immune systems interact in host defense is important,
integrating a system that senses the whole body with one that protects. Understanding the …

Calcitonin gene-related peptide inhibits chemokine production by human dermal microvascular endothelial cells

J Huang, LL Stohl, X Zhou, W Ding… - Brain, behavior, and …, 2011 - Elsevier
This study examined whether the sensory neuropeptide calcitonin gene-related peptide
(CGRP) inhibits release of chemokines by dermal microvascular endothelial cells. Dermal …

Calcitonin gene-related peptide is chemotactic for human T lymphocytes.

CA Foster, B Mandak, E Kromer… - Annals of the New York …, 1992 - europepmc.org
Certain neuropeptides, such as CGRP, are associated with C-type nerve fibers in the skin
and are known to be proinflammatory mediators. Because of their probable role in various …

Expression and distribution of calcitonin receptor-like receptor in human hairy skin

S Hagner, RV Haberberger, D Overkamp, R Hoffmann… - Peptides, 2002 - Elsevier
Calcitonin gene-related peptide and adrenomedullin exert potent effects in skin but their
cellular targets are unknown. This study aimed to identify the cellular location of calcitonin …

Lipopolysaccharide induces calcitonin gene‐related peptide in the RAW264. 7 macrophage cell line

W Ma, Y Dumont, F Vercauteren, R Quirion - Immunology, 2010 - Wiley Online Library
Calcitonin gene‐related peptide (CGRP) is widely distributed and plays important roles in a
wide array of biological functions. It is enriched in primary sensory neurons and hence …

Antiinflammatory activities of CGRP modulating innate immune responses in health and disease

B Holzmann - Current Protein and Peptide Science, 2013 - ingentaconnect.com
Sensory nerves are abundant in lymphoid organs and rapidly release the neuropeptide
calcitonin gene-related peptide (CGRP) in response to injury or infection. CGRP directly acts …