Nutritional and metabolic factors in amyotrophic lateral sclerosis

A Ludolph, L Dupuis, E Kasarskis, F Steyn… - Nature Reviews …, 2023 - nature.com
Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease that is
classically thought to impact the motor system. Over the past 20 years, research has started …

Altered metabolic homeostasis in amyotrophic lateral sclerosis: mechanisms of energy imbalance and contribution to disease progression

ZA Ioannides, ST Ngo, RD Henderson… - Neurodegenerative …, 2016 - karger.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
the death of motor neurones, which leads to paralysis and death in an average of 3 years …

Exploring targets and therapies for amyotrophic lateral sclerosis: current insights into dietary interventions

ST Ngo, JD Mi, RD Henderson… - Degenerative …, 2017 - Taylor & Francis
A growing number of preclinical and human studies demonstrate a disease-modifying effect
of nutritional state in amyotrophic lateral sclerosis (ALS). The management of optimal …

[HTML][HTML] Metabolic dysfunctions in amyotrophic lateral sclerosis pathogenesis and potential metabolic treatments

TW Tefera, K Borges - Frontiers in neuroscience, 2017 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease primarily
characterized by loss of motor neurons in brain and spinal cord. The death of motor neurons …

Nutritional state, energy intakes and energy expenditure of amyotrophic lateral sclerosis (ALS) patients

L Genton, V Viatte, JP Janssens, AC Héritier, C Pichard - Clinical nutrition, 2011 - Elsevier
Amyotrophic lateral sclerosis (ALS) alters nutritional state, energy intake and energy
expenditure. This article aims at reviewing present knowledge on these topics in order to …

[HTML][HTML] Altered bioenergetics and metabolic homeostasis in amyotrophic lateral sclerosis

AT Nelson, D Trotti - Neurotherapeutics, 2022 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that
primarily affects motor neurons and causes muscle atrophy, paralysis, and death. While a …

Understanding and managing metabolic dysfunction in Amyotrophic Lateral Sclerosis

H Blasco, D Lanznaster, C Veyrat-Durebex… - Expert Review of …, 2020 - Taylor & Francis
ABSTRACT Introduction Amyotrophic Lateral Sclerosis (ALS) is a fatal motor neuron disease
that leads to death after a median survival of 36 months. The development of an effective …

[HTML][HTML] Metabolic abnormalities, dietary risk factors and nutritional management in amyotrophic lateral sclerosis

E D'Amico, G Grosso, JW Nieves, A Zanghì… - Nutrients, 2021 - mdpi.com
Amyotrophic Lateral Sclerosis (ALS) is a devastating progressive neurodegenerative
disease that affects motor neurons, leading to a relentless paralysis of skeletal muscles and …

[HTML][HTML] Energy metabolism in ALS: an underappreciated opportunity?

T Vandoorne, K De Bock, L Van Den Bosch - Acta neuropathologica, 2018 - Springer
Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive and fatal
neurodegenerative disorder that primarily affects motor neurons. Despite our increased …

Nutrition and dietary supplements in motor neuron disease

J Rosenfeld, A Ellis - Physical medicine and rehabilitation clinics of North …, 2008 - Elsevier
Compromised nutrition leading to weight loss is a common and significant problem in the
amyotrophic lateral sclerosis (ALS) patient population. The benefit of aggressive and early …