The aim of this study was to establish an in vitro method for evaluating the effect of
supersaturation on oral absorption of poorly water-soluble drugs in vivo. Albendazole …

Purpose Delaying precipitation of weakly basic drugs in supersaturated state following their
transition from the acidic gastric environment to the near-neutral proximal small intestinal …

This study aimed to elucidate the relationship between supersaturation and precipitation
and the effect of a supersaturated state on drug membrane permeation. Stock solutions of …

The purpose of this study is to clarify the effects of intestinal drug supersaturation on
solubility-limited nonlinear absorption. Oral absorption of a novel farnesyltransferase …

In this study, a multipronged approach of in vitro experiments, in silico simulations, and in
vivo studies was developed to evaluate the dissolution, supersaturation, precipitation, and …

In order to better understand the oral absorption behavior of poorly water-soluble drugs,
their supersaturation–nucleation behavior was characterized in fasted state simulated …

This study evaluated the fasted state gastrointestinal behavior of the lipophilic drug
itraconazole, orally administered to healthy volunteers as either a solid dispersion …

The aim of this study is to evaluate how supersaturation, precipitation, and re-dissolution
processes influence the intestinal absorption of cinnarizine (CNZ), a lipophilic weak base, by …

The present study investigated the ability of the in vitro transfer model and an in vivo
pharmacokinetic study in rats to investigate the supersaturation and precipitation behaviour …

The development of formulations and the assessment of oral drug absorption for
Biopharmaceutical Classification System (BCS) class IIb drugs is often a difficult issue due to …