Context: Mutations in transcription factors result in combined pituitary hormone deficiency
(CPHD). Objective: A genetic screening strategy, based on endocrine and neuroradiological …

Definition Congenital hypopituitarism is characterized by multiple pituitary hormone
deficiency, including somatotroph, thyrotroph, lactotroph, corticotroph or gonadotroph …

Context: Mutations of multiple transcription factor genes involved in pituitary development
have been identified in a minor portion of patients with combined pituitary hormone …

Objective Combined pituitary hormonal deficiency (CPHD) can result from mutations within
genes that encode transcription factors. This study evaluated the frequency of mutations in …

Abstract Background/Aims: Mutation frequencies of genes involved in combined pituitary
hormone deficiency (CPHD) vary substantially between populations. The HYPOPIT study …

Objective: Mutations in the genes encoding pituitary transcription factors (mainly PROP1,
POUF1 and HESX1) are responsible for familial combined pituitary hormone deficiency …

Objectives Mutations in the genes encoding the transcription factors PROP1 and POUF‐1
(Pit‐1) have been reported as common causes of combined pituitary hormone deficiency …

The past 12 years have witnessed an explosion in our understanding of the development of
the anterior pituitary gland, and of mechanisms that underlie the diagnosis of growth …

To investigate the specific mutations in PROP1, POU1F1, LHX3, and HESX1 genes in
patients with combined pituitary hormone deficiency (CPHD) in Turkey. Seventy-six patients …

Summary objective Mutations in the gene for the POU domain transcription factor POU1F1
(human Pit‐1) have been reported in patients with GH, TSH and PRL deficiencies. PROP1 …