Bone physiology relies on the delicate balance between resorption and formation of its
tissue. Bone resorption depends on a process called osteoclastogenesis in which bone …

Just a decade ago, the outlook appeared limitless for the use of bisphosphonates for the
treatment of a large number of metabolic bone diseases ranging from osteoporosis to cancer …

Abstract Purpose of Review Osteonecrosis of the jaw (ONJ) is a rare and severe necrotic
bone disease reflecting a compromise in the body's osseous healing mechanisms and …

Bisphosphonates are used in the treatment of hypercalcemia of malignancy, skeletal
complications associated with metastastic bone disease, Paget's disease, and osteoporosis …

Although osteonecrosis of the jaws (ONJ), a serious complication of antiresorptive
medications, was reported a decade ago, the exact mechanisms of disease pathophysiology …

Since the first article about bisphosphonate-related osteonecrosis of the jaw (BRONJ) was
published in 2003, clinical and basic research for BRONJ has continued worldwide to …

Osteoclasts are large multinucleated cells from hematopoietic origin and are responsible for
bone resorption. A balance between osteoclastic bone resorption and osteoblastic bone …

In recent years, medication‐related osteonecrosis of the jaw (MRONJ) became an arising
disease due to the important antiresorptive drug prescriptions to treat oncologic and …

The pathogenesis of medication-related osteonecrosis of the jaw (MRONJ) is multifactorial
and there is a substantial consensus on the role of antiresorptive drugs (ARDs), including …

Antiresorptive medications are essential in treating diseases of pathologic osteoclastic bone
resorption, including bone cancer and osteoporosis. Bisphosphonates (BPs) are the most …