A hallmark of the immune system is the interplay among specialized cell types transitioning
between resting and stimulated states. The gene regulatory landscape of this dynamic …

Here, we survey variation and dynamics of active regulatory elements genome-wide using
longitudinal samples from human individuals. We applied Assay of Transposase Accessible …

Over 90% of genetic variants associated with complex human traits map to non-coding
regions, but little is understood about how they modulate gene regulation in health and …

Immune-disease-associated variants are enriched in active chromatin regions of T cells and
macrophages. However, whether these variants function in specific cell states is unknown …

The human immune system displays substantial variation between individuals, leading to
differences in susceptibility to autoimmune disease. We present single-cell RNA sequencing …

Genetic studies have revealed that autoimmune susceptibility variants are over-represented
in memory CD4+ T cell regulatory elements,–. Understanding how genetic variation affects …

In autoimmune diseases such as rheumatoid arthritis, the immune system attacks the body's
own cells. Developing a precise understanding of the cell states where noncoding …

During activation, T cells undergo extensive gene expression changes that shape the
properties of cells to exert their effector function. Understanding the regulation of this …

Regulatory variants are often context specific, modulating gene expression in a subset of
possible cellular states. Although these genetic effects can play important roles in disease …

Genome-wide association studies (GWASs) have uncovered hundreds of autoimmune
disease-associated loci; however, the causal genetic variants within each locus are mostly …