Histopathology based studies of the pancreas obtained from organ donors are increasing
our awareness of islet phenotypic heterogeneity during development and aging, as well as …

Background Amyloid deposits are a typical finding in pancreatic islets from patients with type
2 diabetes. Whether this is linked to the pathogenesis of type 2 diabetes is currently …

Aims: Islet amyloid is a hallmark in type 2 diabetic subjects, but its implication in clinical
features and development of islet pathology is still unclear. Methods: From 118 autopsy …

Objectives: Type 2 diabetes mellitus is characterized histopathologically by islet amyloid
deposits formed from islet amyloid polypeptide. The aim of this study was to investigate sex …

Diabetes mellitus is one of the most common metabolic diseases worldwide and its
prevalence is rapidly increasing. Due to its chronic nature (diabetes mellitus can be treated …

Amyloid deposition and reduced β-cell mass are pathological hallmarks of the pancreatic
islet in type 2 diabetes; however, whether the extent of amyloid deposition is associated with …

β-Cell dysfunction is an important factor in the development of hyperglycemia of type-2
diabetes mellitus, and pancreatic islet amyloidosis (IA) has been postulated to be one of the …

Islet amyloid occurs in> 90% of type 2 diabetic patients and may play a role in the
pathogenesis of this disease. To determine whether islet amyloid occurs diffusely throughout …

Islet amyloid has been suggested to be an important link between insulin resistance and β-
cell dysfunction in type 2 diabetes. To investigate the prevalence and clinicopathological …

Pancreatic islets have only recently reemerged as a site of a causative pathology in type 2
diabetes as a result of the identification in 1987-1988 of the peptide which is the principal …