Expression patterns of ShcD and Shc family adaptor proteins during mouse embryonic development
SP Hawley, MKB Wills, AJ Rabalski… - Developmental …, 2011 - Wiley Online Library
The Src homology and collagen (Shc) proteins function as molecular adaptors in signaling
pathways mediated by a variety of cell surface receptors. Of the four mammalian Shc …
pathways mediated by a variety of cell surface receptors. Of the four mammalian Shc …
Teaching an old dogma new tricks: twenty years of Shc adaptor signalling
Shc (Src homology and collagen homology) proteins are considered prototypical signalling
adaptors in mammalian cells. Consisting of four unique members, ShcA, B, C and D, and …
adaptors in mammalian cells. Consisting of four unique members, ShcA, B, C and D, and …
pH‐Dependent self‐association of the Src homology 2 (SH2) domain of the Src homologous and collagen‐like (SHC) protein
The Src homologous and collagen‐like (SHC) protein plays an essential role in signal
transduction pathways in that it participates in the chain of events that leads to the activation …
transduction pathways in that it participates in the chain of events that leads to the activation …
[HTML][HTML] Signaling adaptor ShcD suppresses extracellular signal-regulated kinase (Erk) phosphorylation distal to the Ret and Trk neurotrophic receptors
Proteins of the Src homology and collagen (Shc) family are typically involved in signal
transduction events involving Ras/MAPK and PI3K/Akt pathways. In the nervous system …
transduction events involving Ras/MAPK and PI3K/Akt pathways. In the nervous system …
Indirect recruitment of the signalling adaptor Shc to the fibroblast growth factor receptor 2 (FGFR2)
AC Schüller, Z Ahmed, JA Levitt, KM Suen… - Biochemical …, 2008 - portlandpress.com
The adaptor protein Shc (Src homology and collagen-containing protein) plays an important
role in the activation of signalling pathways downstream of RTKs (receptor tyrosine kinases) …
role in the activation of signalling pathways downstream of RTKs (receptor tyrosine kinases) …
[HTML][HTML] Src homologous and collagen (Shc) protein binds to F-actin and translocates to the cytoskeleton upon nerve growth factor stimulation in PC12 cells
D Thomas, SD Patterson, RA Bradshaw - Journal of Biological Chemistry, 1995 - ASBMB
Immunoprecipitates of metabolically labeled PC12 cells consistently contained a 43-kDa
protein that was associated with Shc, a signal-transducing protein with a single SH2 domain …
protein that was associated with Shc, a signal-transducing protein with a single SH2 domain …
[HTML][HTML] A cryptic targeting signal induces isoform-specific localization of p46Shc to mitochondria
A Ventura, M Maccarana, VA Raker… - Journal of Biological …, 2004 - ASBMB
The human Src homology and collagen (Shc) gene encodes three protein isoforms of 46,
52, and 66 kDa that belong to a family of molecular adapters involved in several signal …
52, and 66 kDa that belong to a family of molecular adapters involved in several signal …
Combinatorial ShcA docking interactions support diversity in tissue morphogenesis
Changes in protein-protein interactions may allow polypeptides to perform unexpected
regulatory functions. Mammalian ShcA docking proteins have amino-terminal …
regulatory functions. Mammalian ShcA docking proteins have amino-terminal …
[HTML][HTML] Functional importance of amino-terminal domain of Shc for interaction with insulin and epidermal growth factor receptors in phosphorylation-independent …
T Sasaoka, H Ishihara, T Sawa, M Ishiki… - Journal of Biological …, 1996 - ASBMB
Shc has two distinct domains, amino-terminal and SH2 domain, which can interact with
activated growth factor receptors. Shc interacts with insulin receptor via Shc-amino-terminal …
activated growth factor receptors. Shc interacts with insulin receptor via Shc-amino-terminal …
[HTML][HTML] Defining the specificity space of the human SRC homology 2 domain
Src homology 2 (SH2) domains are the largest family of interaction modules encoded by the
human genome to recognize tyrosine-phosphorylated sequences and thereby play pivotal …
human genome to recognize tyrosine-phosphorylated sequences and thereby play pivotal …