Current efforts in the vitamin D field are directed toward the development of highly
antiproliferative yet noncalcemic analogues of the natural hormone 1α, 25-dihydroxyvitamin …

The toxic calcemic effects of the natural hormone 1α, 25-dihydroxyvitamin D3 (1, 25D3, 1, 25-
dihydroxycholecalciferol) in the treatment of hyperproliferative diseases demand the …

Continuing the structure–activity relationship studies in the vitamin D area, we designed and
synthesized novel C-9 substituted calcitriol analogues, possessing different nonpolar groups …

Two novel vitamin D analogues of the hormone 1α, 25-(OH) 2D3 modified at C-7, namely, 7-
methyl-1α, 25-(OH) 2D3 (12) and 7-methyl-1α, 25-(OH) 2-19-nor-D3 (26), were synthesized …

Convergent syntheses of three new analogues of 1α, 25-dihydroxyvitamin D3 with α-
hydroxyalkyl substituents at C12 (4a–c) are described. The A-ring and triene system of each …

The vitamin D hormone, 1α, 25‐dihydroxyvitamin D3 [1, 25‐(OH) 2D3], exerts its hormonal
effects predominantly on intestine, bone, and kidney, where it plays a crucial role in calcium …

As a continuation of our efforts directed to the structure-activity relationship studies of vitamin
D compounds, we present in this paper the synthesis of new analogues of 1α, 25-(OH) 2 D 3 …

As a continuation of our studies on structure–activity relationship of vitamin D compounds
we synthesized new calcitriol analogs characterized by the presence of an exomethylene …

Among more than 3000 analogs of 1α, 25-dihydroxyvitamin D3 synthesized to date, only a
few were characterized by structural modifications in the seco-B-ring. The compounds …

Structure-guided optimization was used to design new analogues of 1α, 25-
dihydroxyvitamin D3 bearing the main side chain at C12 and a shorter second hydroxylated …