Inflammatory pain is the perception of noxious stimuli that occurs during inflammation or an
immune response. Glial cells are widespread in the central and peripheral nervous systems …

The role of central glial cells in the mechanisms underlying pain has been intensively
studied in the last two decades. Most studies on glia and pain focused on the potential …

Management of chronic pain is a real challenge, and current treatments that focus on
blocking neurotransmission in the pain pathway have resulted in limited success. Activation …

Glia have emerged as key contributors to pathological and chronic pain mechanisms. On
activation, both astrocytes and microglia respond to and release a number of signalling …

During neuropathic pain, glial cells (mainly astrocytes and microglia) become activated and
initiate a series of signaling cascades that modulate pain processing at both spinal and …

Over the last decade, a series of studies has demonstrated that glia in the central nervous
system play roles in many aspects of neuronal functioning including pain processing …

Over the past few years, the control of pain exerted by glial cells has emerged as a
promising target against pathological pain. Indeed, changes in glial phenotypes have been …

Interactions between central glial cells and neurons in the pain circuitry are critical
contributors to the pathogenesis of chronic pain. In the central nervous system (CNS), two …

Neuropathic pain, whose symptoms are characterized by spontaneous and irritation-
induced painful sensations, is a condition that poses a global burden. Numerous …

Neuropathic pain refers to a variety of chronic pain conditions with differing underlying
pathophysiologic mechanisms and origins. Recent studies indicate a communication …