For many years, stem cell metabolism was viewed as a byproduct of cell fate status rather
than an active regulatory mechanism; however, there is now a growing appreciation that …

The environment surrounding stem cells has the ability to elicit profound, heritable
epigenetic changes orchestrated by multiple epigenetic mechanisms, which can be …

Engineering pluripotency through nuclear reprogramming and directing stem cells into
defined lineages underscores cell fate plasticity. Acquisition of and departure from stemness …

Energy metabolism is traditionally considered a reactive homeostatic system addressing
stage-specific cellular energy needs. There is however growing appreciation of metabolic …

Highlights•Regulation is highly-dynamic, cell-type specific and involved in cell fate
determination.•Aerobic glycolysis is a feature of 'primed'pluripotent cells and widely seen in …

Plasticity in energy metabolism allows stem cells to match the divergent demands of self-
renewal and lineage specification. Beyond a role in energetic support, new evidence …

A distinctive feature of stem cells is their capacity to self-renew to maintain pluripotency.
Studies of genetically-engineered mouse models and recent advances in metabolomic …

Metabolism is influenced by age, food intake, and conditions such as diabetes and obesity.
How do physiological or pathological metabolic changes influence stem cells, which are …

The bioenergetics of somatic dedifferentiation into induced pluripotent stem cells remains
largely unknown. Here, stemness factor-mediated nuclear reprogramming reverted …

Advances in metabolomics have deepened our understanding of the roles that specific
modes of metabolism play in programming stem cell fates. Here, we review recent …