An expanded series of alkyl 2-arylhydrazinylidene-3-oxo-3-polyfluoroalkylpropionates
(HOPs) 3 was obtained via Cu (OAc) 2-catalyzed azo coupling. All were nanomolar …

Mammalian carboxylesterases are key serine hydrolases that catalyze the hydrolysis of a
wide variety of ester compounds in the corresponding carboxylic acids and alcohols. In …

Mammalian carboxylesterases (CEs) are important serine hydrolases catalyzing the
hydrolysis of ester-or amide-containing compounds into the corresponding alcohols and …

To search for effective and selective inhibitors of carboxylesterase (CES), a series of 3-oxo-2-
tolylhydrazinylidene-4, 4, 4-trifluorobutanoates bearing higher or natural alcohol moieties …

Human carboxylesterases (hCEs) are key enzymes from the serine hydrolase superfamily.
Among all identified hCEs, human carboxylesterase 2 (hCE2) plays crucial roles in the …

Carboxylesterases (CE) are ubiquitous enzymes responsible for the metabolism of
xenobiotics. Because the structural and amino acid homology among esterases of different …

Inhibition of intestinal carboxylesterases may allow modification of the pharmacokinetics/
pharmacodynamic profile of existing drugs by altering half-life or toxicity. Since previously …

Abstract Human carboxylesterase 1 (CES1), primarily expressed in the liver and adipocytes,
is responsible for the hydrolysis of endogenous esters (such as cholesteryl esters and …

Abstract A series of 2-arylhydrazinylidene-3-oxo-4, 4, 4-trifluorobutanoic acids was
synthesized via dealkylation of ethyl 2-arylhydrazinylidene-3-oxo-4, 4, 4-trifluorobutanoates …

Background: Esterase is an enzyme that splits esters into an acid and alcohol. Varieties of
esterases are present in human body to control diverse set of cellular processes and …