Background: Phosphoinositide 3-kinase (PI3Ks) is a member of intracellular lipid kinases
and involved in the regulation of cellular proliferation, differentiation and survival …

Cancer is the second leading cause of human death globally. PI3K/Akt/mTOR signaling is
one of the most frequently dysregulated signaling pathways observed in cancer patients that …

The phosphoinositide 3 kinase AKT mammalian target of rapamycin (PI3K-AKTmTOR)
signaling pathway is an important in the aetiology of pancreatic cancer (PC) and is …

Abstract PI3K/AKT/mTOR pathway is one of the most important signaling pathways involved
in normal cellular processes. Its aberrant activation modulates autophagy, epithelial …

Although pancreatic cancer (PC) was considered in the past an orphan cancer type due to
its low incidence, it may become in the future one of the leading causes of cancer death …

Hepatocellular carcinoma (HCC) is a complex biological process and is often diagnosed at
advanced stages with no effective treatment options. With advances in tumor biology and …

Targeting of pathways downstream of RAS represents a promising therapeutic strategy for
pancreatic cancer, the fourth leading cause of cancer-related death in the USA, since …

The epidermal growth factor receptor (EGFR) pathway and Hippo signaling play an
important role in the carcinogenesis of hepatocellular carcinoma (HCC). However, the …

Simple Summary Pancreatic cancer has a dismal 5-year survival rate of 10%, making it one
of the deadliest forms of malignancy. The poor prognosis associated with this disease is …

Mitophagy is a type of selective macroautophagy/autophagy that degrades dysfunctional or
excessive mitochondria. Regulation of this process is critical for maintaining cellular …