Mechanistic target of rapamycin (mTOR) regulates cell growth, metabolism and aging in
response to nutrients, cellular energy stage and growth factors. mTOR is frequently up …

Esophageal cancer is the sixth most common cause of cancer-related deaths worldwide.
Novel therapeutic intervention is urgently needed for this deadly disease. The functional role …

Aberrations in various cellular signaling pathways are instrumental in regulating cellular
metabolism, tumor development, growth, proliferation, metastasis and cytoskeletal …

The phosphoinositide 3-kinase (PI3K) pathway plays an integral role in many cellular
processes and is frequently altered in cancer, contributing to tumor growth and survival …

Cancer stem cells (CSCs) are a subpopulation of tumor cells that possess unique self-
renewal activity and mediate tumor initiation and propagation. The PI3K/Akt/mTOR signaling …

It is well established that the PI3K pathway plays a central role in various cellular processes
that can contribute to the malignant phenotype. Accordingly, pharmacological inhibition of …

Cancer stem cells (CSCs) as a small subpopulation in tumor bulk are believed to initiate
tumor formation and are responsible for the resistance to cancer therapy. The proliferation …

Metabolic reprogramming plays a crucial role in the development of hepatocellular
carcinoma (HCC). However, the key drivers of metabolic reprogramming underlying HCC …

Primary liver cancers, including hepatocellular carcinoma (HCC) and intrahepatic
cholangiocarcinoma (iCCA), are highly lethal tumors, with high worldwide frequency and …

Abstract Background Forkhead box M1 (FOXM1) is a proliferation-associated transcription
factor of the forkhead box proteins superfamily, which includes four isoforms FOXM1a, b, c …