An ever-increasing demand for novel antimicrobials to treat life-threatening infections
caused by the global spread of multidrug-resistant bacterial pathogens stands in stark …

The public view on antibiotics as reliable medicines changed when reports about “resistant
superbugs” appeared in the news. While reasons for this resistance development are easily …

New antibiotics are necessary to treat microbial pathogens that are becoming increasingly
resistant to available treatment. Despite the medical need, the number of newly approved …

We are facing a potential catastrophe of untreatable bacterial infections, driven by the
inexorable rise of extensively drug-resistant bacteria, coupled with a market failure of …

The widespread emergence of antibiotic-resistant pathogens poses a severe threat to public
health. This problem becomes even worse with a coincident decline in the supply of new …

The introduction of effective antibacterial therapies for infectious diseases in the mid‐20th
century completely revolutionized clinical practices and helped to facilitate the development …

The world is facing a crisis in treating infectious diseases, with a scarcity of new antibiotics in
development to treat the growing threat of drug-resistant “superbugs”. We need new …

Since their discovery in the early 20th century, antibiotics have been used as the primary
weapon against bacterial infections. Due to their prophylactic effect, they are also used as …

Ever since the world‐shaping discovery of penicillin, nature's molecular diversity has been
extensively screened for new medications and lead compounds in drug discovery. The …

There is a continuous need for iterative cycles of antibiotic discovery and development to
deal with the selection of resistant pathogens that emerge as therapeutic application of an …