NLR receptors in plant immunity: making sense of the alphabet soup

MP Contreras, D Lüdke, H Pai, AA Toghani… - EMBO …, 2023 - embopress.org
Plants coordinately use cell‐surface and intracellular immune receptors to perceive
pathogens and mount an immune response. Intracellular events of pathogen recognition are …

[HTML][HTML] NLR diversity, helpers and integrated domains: making sense of the NLR IDentity

E Baggs, G Dagdas, KV Krasileva - Current opinion in plant biology, 2017 - Elsevier
Highlights•Plant NLR immune receptors are rapidly diversifying modular proteins.•There is a
vast diversity in NLR copy number and allelic variation across species.•NLRs are sensors of …

Activation and regulation of NLR immune receptor networks

J Kourelis, H Adachi - Plant and Cell Physiology, 2022 - academic.oup.com
Plants have many types of immune receptors that recognize diverse pathogen molecules
and activate the innate immune system. The intracellular immune receptor family of …

Animal NLRs provide structural insights into plant NLR function

A Bentham, H Burdett, PA Anderson… - Annals of …, 2017 - academic.oup.com
Background The plant immune system employs intracellular NLRs (nucleotide binding [NB],
leucine-rich repeat [LRR]/nucleotide-binding oligomerization domain [NOD]-like receptors) …

NLR functions in plant and animal immune systems: so far and yet so close

T Maekawa, TA Kufer, P Schulze-Lefert - Nature immunology, 2011 - nature.com
In plants and animals, the NLR family of receptors perceives non-self and modified-self
molecules inside host cells and mediates innate immune responses to microbial pathogens …

Structural, functional, and genomic diversity of plant NLR proteins: an evolved resource for rational engineering of plant immunity

F Monteiro, MT Nishimura - Annual review of phytopathology, 2018 - annualreviews.org
Plants employ a diverse intracellular system of NLR (nucleotide binding–leucine-rich repeat)
innate immune receptors to detect pathogens of all types. These receptors represent …

NLR singletons, pairs, and networks: evolution, assembly, and regulation of the intracellular immunoreceptor circuitry of plants

H Adachi, L Derevnina, S Kamoun - Current opinion in plant biology, 2019 - Elsevier
Highlights•NLRs may have evolved from singletons to pairs and networks.•Assembly of
immunoreceptor complexes is associated with NLR activation.•NLR (mis) regulation …

NLR receptor networks in plants

H Adachi, S Kamoun - Essays in Biochemistry, 2022 - portlandpress.com
To fight off diverse pathogens and pests, the plant immune system must recognize these
invaders; however, as plant immune receptors evolve to recognize a pathogen, the …

[HTML][HTML] The wheels of destruction: plant NLR immune receptors are mobile and structurally dynamic disease resistance proteins

S Shepherd, ELH Yuen, P Carella… - Current Opinion in Plant …, 2023 - Elsevier
Nucleotide-binding leucine-rich repeat (NLR) proteins are intracellular immune receptors
that restrict plant invasion by pathogens. Most NLRs operate in intricate networks to detect …

Structure-informed insights for NLR functioning in plant immunity

OCA Sukarta, EJ Slootweg, A Goverse - Seminars in Cell & Developmental …, 2016 - Elsevier
To respond to foreign invaders, plants have evolved a cell autonomous multilayered
immune system consisting of extra-and intracellular immune receptors. Nucleotide binding …